-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, BSq3oNQnB9t5DBxmg8i+xAKd5+n0/6Xbo6tA8/nJfAqeuUN5PIxi5FTC4X/mV6I5 GV39s0mRgtAXScK3UWQWdA== 0001172661-10-000672.txt : 20101115 0001172661-10-000672.hdr.sgml : 20101115 20101115172016 ACCESSION NUMBER: 0001172661-10-000672 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20100930 FILED AS OF DATE: 20101115 DATE AS OF CHANGE: 20101115 EFFECTIVENESS DATE: 20101115 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 101194030 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR 1 orb3q10.txt FORM 13F HOLDINGS REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: September 30, 2010 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors, LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY November 15, 2010 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 99 Form13F Information Table Value Total: $2,888,550 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 Orbimed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE - ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- ABBOTT LABS COM 002824100 19355 370500 SH DEFINED 1 237000 0 133500 ACHILLION PHARMACEUTICALS IN COM 00448Q201 3162 1047100 SH DEFINED 1 703200 0 343900 AETNA INC NEW COM 00817Y108 36655 1159600 SH DEFINED 1 963600 0 196000 AFFYMETRIX INC COM 00826T108 6556 1437700 SH DEFINED 1 1221900 0 215800 ALCON INC COM SHS H01301102 54207 325000 SH CALL DEFINED 1 250000 0 75000 ALIGN TECHNOLOGY INC COM 016255101 32454 1657500 SH DEFINED 1 1297500 0 360000 ALLERGAN INC COM 018490102 72285 1086500 SH DEFINED 1 896500 0 190000 ALLOS THERAPEUTICS INC COM 019777101 43101 9131500 SH DEFINED 1 7454500 0 1677000 AMARIN CORP PLC SPONS ADR NEW 023111206 23220 9000000 SH SOLE 9000000 0 0 AMGEN INC COM 031162100 157697 2861500 SH DEFINED 1 1858500 0 1003000 AMYLIN PHARMACEUTICALS INC COM 032346108 5213 250000 SH PUT DEFINED 1 125000 0 125000 ANADYS PHARMACEUTICALS INC COM 03252Q408 4570 1969900 SH DEFINED 1 1969900 0 0 ANTARES PHARMA INC COM 036642106 8824 6085700 SH DEFINED 1 3952800 0 2132900 ANTHERA PHARMACEUTICALS INC COM 03674U102 14454 3449734 SH DEFINED 1 3449734 0 0 ARENA PHARMACEUTICALS INC COM 040047102 942 600000 SH PUT DEFINED 1 300000 0 300000 ARIAD PHARMACEUTICALS INC COM 04033A100 6595 1726500 SH DEFINED 1 1726500 0 0 ATHERSYS INC COM 04744L106 5506 1805100 SH SOLE 1805100 0 0 AVEO PHARMACEUTICALS INC COM 053588109 10082 905000 SH DEFINED 1 621100 0 283900 BARD C R INC COM 067383109 4886 60000 SH DEFINED 1 0 0 60000 BAXTER INTL INC COM 071813109 37929 795000 SH DEFINED 1 425000 0 370000 BAXTER INTL INC COM 071813109 19084 400000 SH CALL DEFINED 1 286500 0 113500 BIOGEN IDEC INC COM 09062X103 21084 375700 SH 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1353500 SH DEFINED 1 1353500 0 0 DENDREON CORP COM 24823Q107 59666 1448900 SH DEFINED 1 1196800 0 252100 DENDREON CORP NOTE 4.750% 6/1 24823QAB3 4090 1000000 PRN DEFINED 1 1000000 0 0 ELAN PLC ADR 284131208 44051 7661000 SH DEFINED 1 6361000 0 1300000 ENDO PHARMACEUTICALS HLDGS I COM 29264F205 84270 2535200 SH DEFINED 1 2049700 0 485500 GENZYME CORP COM 372917104 115572 1632600 SH DEFINED 1 1343600 0 289000 GILEAD SCIENCES INC COM 375558103 119180 3346800 SH DEFINED 1 2378800 0 968000 GIVEN IMAGING ORD SHS M52020100 11745 652500 SH DEFINED 1 377500 0 275000 HOSPIRA INC COM 441060100 8552 150000 SH CALL DEFINED 1 102500 0 47500 HOSPIRA INC COM 441060100 63064 1106200 SH DEFINED 1 875200 0 231000 HUMAN GENOME SCIENCES INC COM 444903108 75550 2536100 SH DEFINED 1 2003800 0 532300 ILLUMINA INC COM 452327109 74518 1514600 SH DEFINED 1 1224600 0 290000 IMMUCOR INC COM 452526106 1315 66300 SH CALL DEFINED 1 33900 0 32400 INCYTE CORP COM 45337C102 1580 98800 SH CALL DEFINED 1 69100 0 29700 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62936P103 1881 275000 SH PUT DEFINED 1 157400 0 117600 NPS PHARMACEUTICALS INC COM 62936P103 27128 3966100 SH DEFINED 1 3806100 0 160000 NPS PHARMACEUTICALS INC COM 62936P103 1881 275000 SH CALL DEFINED 1 157400 0 117600 NXSTAGE MEDICAL INC COM 67072V103 70670 3700000 SH SOLE 3700000 0 0 ORASURE TECHNOLOGIES INC COM 68554V108 3101 765600 SH DEFINED 1 509300 0 256300 OREXIGEN THERAPEUTICS INC COM 686164104 13965 2355000 SH DEFINED 1 1803000 0 552000 PERRIGO CO COM 714290103 9877 153800 SH CALL DEFINED 1 85800 0 68000 PERRIGO CO COM 714290103 31211 486000 SH DEFINED 1 448000 0 38000 PFIZER INC COM 717081103 154049 8972000 SH DEFINED 1 7281000 0 1691000 PHARMACYCLICS INC COM 716933106 43822 5423500 SH DEFINED 1 4173500 0 1250000 PHARMACYCLICS INC COM 716933106 4848 600000 SH CALL DEFINED 1 422500 0 177500 PHARMASSET INC COM 71715N106 6694 227300 SH DEFINED 1 172300 0 55000 SAVIENT PHARMACEUTICALS INC COM 80517Q100 16901 739000 SH DEFINED 1 640000 0 99000 SEATTLE GENETICS INC COM 812578102 29793 1918400 SH DEFINED 1 1604300 0 314100 SEQUENOM INC COM NEW 817337405 7179 1024100 SH DEFINED 1 1024100 0 0 SHIRE PLC SPONSORED ADR 82481R106 90519 1345400 SH DEFINED 1 1151300 0 194100 SOLTA MED INC COM 83438K103 986 492900 SH DEFINED 1 320000 0 172900 STRYKER CORP COM 863667101 18989 379400 SH DEFINED 1 225000 0 154400 SUPERGEN INC COM 868059106 4138 1979700 SH DEFINED 1 1241900 0 737800 SYNERON MEDICAL LTD ORD SHS M87245102 3615 364400 SH DEFINED 1 225400 0 139000 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 5185 98300 SH DEFINED 1 98300 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 62981 1315400 SH DEFINED 1 900800 0 414600 TOMOTHERAPY INC COM 890088107 4301 1222000 SH DEFINED 1 922000 0 300000 TRANSCEPT PHARMACEUTICALS IN COM 89354M106 1641 235500 SH DEFINED 1 235500 0 0 UNITEDHEALTH GROUP INC COM 91324P102 39214 1116900 SH DEFINED 1 920900 0 196000 VERTEX PHARMACEUTICALS INC COM 92532F100 54917 1588567 SH DEFINED 1 1299867 0 288700 VOLCANO CORPORATION COM 928645100 6495 250000 SH CALL DEFINED 1 175000 0 75000 VOLCANO CORPORATION COM 928645100 3767 145000 SH DEFINED 1 145000 0 0 WARNER CHILCOTT PLC IRELAND SHS A G94368100 5610 250000 SH CALL DEFINED 1 175000 0 75000 WARNER CHILCOTT PLC IRELAND SHS A G94368100 70287 3132200 SH DEFINED 1 2636200 0 496000 WATERS CORP COM 941848103 7078 100000 SH DEFINED 1 0 0 100000 WATSON PHARMACEUTICALS INC COM 942683103 10578 250000 SH CALL DEFINED 1 125000 0 125000 WATSON PHARMACEUTICALS INC COM 942683103 22255 526000 SH DEFINED 1 266000 0 260000 WELLPOINT INC COM 94973V107 35683 630000 SH DEFINED 1 512000 0 118000 WELLPOINT INC COM 94973V107 14160 250000 SH CALL DEFINED 1 175000 0 75000 ZIMMER HLDGS INC COM 98956P102 22894 437500 SH DEFINED 1 315000 0 122500 ZIMMER HLDGS INC COM 98956P102 13083 250000 SH CALL DEFINED 1 175000 0 75000
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