-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, DW6Wbct0wYq9mzy+uI3euDynyWwjzTHEJe94fJGeYFXgpySvPWH6298if31g4ato KzTXXW6JN6yxIf+NWP3MAw== 0001172661-10-000346.txt : 20100517 0001172661-10-000346.hdr.sgml : 20100517 20100517100451 ACCESSION NUMBER: 0001172661-10-000346 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20100331 FILED AS OF DATE: 20100517 DATE AS OF CHANGE: 20100517 EFFECTIVENESS DATE: 20100517 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 10836155 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR 1 orb1q10.txt FORM 13F HOLDINGS REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: March 31, 2010 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors, LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY May 17, 2010 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 105 Form13F Information Table Value Total: $3,384,813 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 OrbiMed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE - ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- ABBOTT LABS COM 002824100 19518 370500 SH SOLE 237000 0 133500 ACORDA THERAPEUTICS INC COM 00484M106 1542 45100 SH DEFINED 1 45100 0 0 AETNA INC NEW COM 00817Y108 29538 841300 SH DEFINED 1 767300 0 74000 AFFYMAX INC COM 00826A109 2179 93000 SH DEFINED 1 93000 0 0 AFFYMETRIX INC COM 00826T108 7839 1068000 SH DEFINED 1 923100 0 144900 ALCON INC COM SHS H01301102 52507 325000 SH CALL DEFINED 1 190000 0 135000 ALEXZA PHARMACEUTICALS INC COM 015384100 6376 2370100 SH DEFINED 1 2370100 0 0 ALIGN TECHNOLOGY INC COM 016255101 34621 1790100 SH DEFINED 1 1465100 0 325000 ALLERGAN INC COM 018490102 78619 1203600 SH DEFINED 1 980900 0 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868059106 7889 2465200 SH DEFINED 1 1548600 0 916600 SYNERON MEDICAL LTD ORD SHS M87245102 2980 272600 SH DEFINED 1 175000 0 97600 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 72523 1149700 SH DEFINED 1 1019700 0 130000 THERMO FISHER SCIENTIFIC INC COM 883556102 86285 1677400 SH DEFINED 1 1287400 0 390000 TOMOTHERAPY INC COM 890088107 3656 1072000 SH DEFINED 1 800400 0 271600 TRANSCEPT PHARMACEUTICALS IN COM 89354M106 2852 357900 SH DEFINED 1 357900 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 33198 600000 SH PUT DEFINED 1 330000 0 270000 UNITEDHEALTH GROUP INC COM 91324P102 26802 820400 SH DEFINED 1 746400 0 74000 VERTEX PHARMACEUTICALS INC COM 92532F100 77468 1895484 SH DEFINED 1 1704784 0 190700 VOLCANO CORPORATION COM 928645100 13892 575000 SH SOLE 575000 0 0 WARNER CHILCOTT PLC IRELAND SHS A G94368100 66773 2616500 SH DEFINED 1 2026000 0 590500 WATERS CORP COM 941848103 6754 100000 SH SOLE 0 0 100000 WELLPOINT INC COM 94973V107 29634 460300 SH DEFINED 1 415300 0 45000 ZIMMER HLDGS 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