-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, Msu+z3iV9t060LyBIknxudBMIoUH/rq0n+kbpR32Q7WLlLSMvAQidFpPnwTsbpTS 3U1Mq8Gtj+O+sU9MmTpb7w== 0001172661-09-000495.txt : 20090303 0001172661-09-000495.hdr.sgml : 20090303 20090303144930 ACCESSION NUMBER: 0001172661-09-000495 CONFORMED SUBMISSION TYPE: 13F-HR/A PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20081231 FILED AS OF DATE: 20090303 DATE AS OF CHANGE: 20090303 EFFECTIVENESS DATE: 20090303 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR/A SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 09651215 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR/A 1 orb4q08amend.txt FORM 13F HOLDINGS REPORT AMENDMENT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: December 31, 2008 Check here if Amendment [ X]; Amendment Number: 1 This Amendment (Check only one.): [ X] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors, LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY March 03, 2009 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 80 Form13F Information Table Value Total: $2,741,710 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 Orbimed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE - ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- ABBOTT LABS COM 002824100 74446 1394900 SH DEFINED 1 1249900 0 145000 AFFYMETRIX INC COM 00826T108 4234 1416000 SH DEFINED 1 1306000 0 110000 AFFYMETRIX INC NOTE 3.500% 1/1 00826TAG3 3040 8000000 SH DEFINED 1 8000000 0 0 ALCON INC COM SHS H01301102 21655 242800 SH DEFINED 1 242800 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 4184 115600 SH DEFINED 1 115600 0 0 ALIGN TECHNOLOGY INC COM 016255101 35546 4062400 SH DEFINED 1 3405900 0 656500 ALLOS THERAPEUTICS INC COM 019777101 29822 4872800 SH DEFINED 1 3872800 0 1000000 ALTUS PHARMACEUTICALS INC COM 02216N105 448 845900 SH DEFINED 1 845900 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 2315 3260870 SH SOLE 3260870 0 0 AMERICAN ORIENTAL BIOENGR IN COM 028731107 2804 413000 SH DEFINED 1 413000 0 0 AMGEN INC COM 031162100 172880 2993600 SH DEFINED 1 2488700 0 504900 ANTARES PHARMA INC COM 036642106 699 1890400 SH DEFINED 1 1316100 0 574300 AP PHARMA INC COM NEW 00202J203 921 2193400 SH DEFINED 1 2193400 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 1746 2054200 SH DEFINED 1 2054200 0 0 ARYX THERAPEUTICS INC COM 043387109 9686 3340139 SH DEFINED 1 3340139 0 0 ASPECT MED SYS INC COM 045235108 1349 395600 SH DEFINED 1 309500 0 86100 ATHERSYS INC COM 04744L106 1552 3448000 SH SOLE 3448000 0 0 AVANIR PHARMACEUTICALS CL A NEW 05348P401 1902 4638759 SH SOLE 4638759 0 0 BAXTER INTL INC COM 071813109 67395 1257600 SH DEFINED 1 973100 0 284500 BECKMAN COULTER INC COM 075811109 5053 115000 SH DEFINED 1 0 0 115000 BECTON DICKINSON & CO COM 075887109 7523 110000 SH DEFINED 1 0 0 110000 BIOCRYST PHARMACEUTICALS COM 09058V103 2561 1869231 SH DEFINED 1 1869231 0 0 BIODEL INC COM 09064M105 8737 1812574 SH DEFINED 1 1812574 0 0 BIOGEN IDEC INC COM 09062X103 144514 3034100 SH DEFINED 1 2552300 0 481800 BIOMARIN PHARMACEUTICAL INC COM 09061G101 63706 3579000 SH DEFINED 1 2973000 0 606000 BRISTOL MYERS SQUIBB CO COM 110122108 146029 6280800 SH DEFINED 1 5380800 0 900000 CELGENE CORP COM 151020104 14887 269300 SH DEFINED 1 269300 0 0 COVANCE INC COM 222816100 2209 48000 SH SOLE 0 0 48000 COVIDIEN LTD COM G2552X108 59180 1633000 SH DEFINED 1 1312000 0 321000 CUBIST PHARMACEUTICALS INC COM 229678107 37098 1535500 SH DEFINED 1 1535500 0 0 CURIS INC COM 231269101 4105 5473711 SH DEFINED 1 5473711 0 0 CYTOKINETICS INC COM 23282W100 11026 3868600 SH DEFINED 1 3868600 0 0 DENDREON CORP COM 24823Q107 5436 1187000 SH DEFINED 1 792000 0 395000 ELAN PLC ADR 284131208 50958 8493000 SH DEFINED 1 7470000 0 1023000 ENTEROMEDICS INC COM 29365M109 657 450000 SH SOLE 0 0 450000 EXELIXIS INC COM 30161Q104 34682 6908800 SH DEFINED 1 5708800 0 1200000 GEN-PROBE INC NEW COM 36866T103 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1254800 0 220000 MEDTRONIC INC COM 585055106 8578 273000 SH SOLE 0 0 273000 MERCK & CO INC COM 589331107 7600 250000 SH DEFINED 1 250000 0 0 MERCK & CO INC COM 589331107 8208 270000 SH SOLE 0 0 270000 MILLIPORE CORP COM 601073109 2937 57000 SH SOLE 0 0 57000 MYLAN INC COM 628530107 45498 4600400 SH DEFINED 1 4225400 0 375000 NEOSE TECHNOLOGIES INC COM 640522108 640 1881000 SH DEFINED 1 1881000 0 0 NPS PHARMACEUTICALS INC COM 62936P103 28762 4631500 SH DEFINED 1 4631500 0 0 NXSTAGE MEDICAL INC COM 67072V103 15268 5718256 SH SOLE 5718256 0 0 ONYX PHARMACEUTICALS INC COM 683399109 95060 2782800 SH DEFINED 1 2447800 0 335000 OSCIENT PHARMACEUTICALS CORP COM NEW 68812R303 511 2836500 SH DEFINED 1 2836500 0 0 OSI PHARMACEUTICALS INC COM 671040103 68697 1759200 SH DEFINED 1 1544200 0 215000 PAR PHARMACEUTICAL COS INC COM 69888P106 38406 2864000 SH DEFINED 1 2346400 0 517600 PFIZER INC COM 717081103 52138 2944000 SH DEFINED 1 2359000 0 585000 PONIARD PHARMACEUTICALS INC COM NEW 732449301 4609 2388300 SH DEFINED 1 2388300 0 0 QLT INC COM 746927102 3907 1621000 SH DEFINED 1 1288100 0 332900 SCHERING PLOUGH CORP COM 806605101 91167 5353300 SH DEFINED 1 4651100 0 702200 SHIRE PLC SPONSORED ADR 82481R106 89600 2000900 SH DEFINED 1 1740900 0 260000 ST JUDE MED INC COM 790849103 4944 150000 SH SOLE 0 0 150000 TARGANTA THERAPEUTICS CORP COM 87612C100 1125 1843909 SH SOLE 1843909 0 0 TARGETED GENETICS CORP COM NEW 87612M306 292 1325000 SH DEFINED 1 1325000 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 7531 176900 SH DEFINED 1 86900 0 90000 THERMO FISHER SCIENTIFIC INC COM 883556102 8518 250000 SH DEFINED 1 0 0 250000 TRIMERIS INC COM 896263100 2491 1859000 SH DEFINED 1 1859000 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 57058 912200 SH DEFINED 1 851800 0 60400 VERTEX PHARMACEUTICALS INC COM 92532F100 113998 3752400 SH DEFINED 1 3312400 0 440000 VIVUS INC COM 928551100 10290 1934200 SH DEFINED 1 1934200 0 0 VOLCANO CORPORATION COM 928645100 28650 1910000 SH DEFINED 1 1910000 0 0 WATERS CORP COM 941848103 2199 60000 SH SOLE 0 0 60000 WYETH COM 983024100 95575 2548000 SH DEFINED 1 2093000 0 455000 XOMA LTD ORD G9825R107 10442 16842171 SH DEFINED 1 13437771 0 3404400
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