-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, S4iZTa/j/yK1p6g89LWyLeMMSdhfYzFIWhqehl4N/JIkRwjZGHtHe+uUCKQV6fKL we/LnZR09l52l1zjzz8XAQ== 0001172661-08-000323.txt : 20080515 0001172661-08-000323.hdr.sgml : 20080515 20080515090020 ACCESSION NUMBER: 0001172661-08-000323 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20080331 FILED AS OF DATE: 20080515 DATE AS OF CHANGE: 20080515 EFFECTIVENESS DATE: 20080515 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 08834180 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR 1 orb1q08.txt FORM 13F HOLDINGS REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: March 31, 2008 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors, LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: Samuel D. Isaly New York, NY May 15, 2008 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 109 Form13F Information Table Value Total: $3,093,319 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 Orbimed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE - ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- ABBOTT LABS COM 002824100 83960 1522400 SH SOLE 1 1522400 0 0 ACHILLION PHARMACEUTICALS IN COM 00448Q201 481 108600 SH SOLE 108600 0 0 ADHEREX TECHNOLOGIES INC COM NEW 00686R200 1589 4940000 SH SOLE 1 4940000 0 0 AFFYMAX INC COM 00826A109 2146 152200 SH SOLE 1 152200 0 0 ALEXION PHARMACEUTICALS INC COM 015351109 4151 70000 SH SOLE 1 70000 0 0 ALEXZA PHARMACEUTICALS INC COM 015384100 7082 1029300 SH SOLE 1 1029300 0 0 ALIGN TECHNOLOGY INC COM 016255101 49845 4486500 SH SOLE 1 3830000 0 656500 ALLERGAN INC COM 018490102 2256 40000 SH SOLE 1 40000 0 0 ALLOS THERAPEUTICS INC COM 019777101 27186 4471400 SH SOLE 1 3571400 0 900000 AMAG PHARMACEUTICALS INC COM 00163U106 26138 646500 SH SOLE 1 508400 0 138100 AMAG PHARMACEUTICALS INC COM 00163U106 10108 250000 SH Call SOLE 1 1750 0 248250 AMERICAN ORIENTAL BIOENGR IN COM 028731107 8729 1077700 SH SOLE 1 1077700 0 0 AMGEN INC COM 031162100 96320 2305400 SH SOLE 1 1879200 0 426200 AMYLIN PHARMACEUTICALS INC COM 032346108 14605 500000 SH SOLE 1 400000 0 100000 ANTARES PHARMA INC COM 036642106 2023 1890400 SH SOLE 1 1316100 0 574300 AP PHARMA INC COM NEW 00202J203 2906 2325000 SH SOLE 1 2325000 0 0 APPLERA CORP COM AP BIO GRP 038020103 7065 215000 SH SOLE 1 0 0 215000 ARIAD PHARMACEUTICALS INC COM 04033A100 4269 1266700 SH SOLE 1266700 0 0 ARQULE INC COM 04269E107 5072 1185000 SH SOLE 1 1185000 0 0 ARYX THERAPEUTICS INC COM 043387109 16898 2125493 SH SOLE 1 2125493 0 0 ASPECT MED SYS INC COM 045235108 6310 1034400 SH SOLE 1 734000 0 300400 ATHERSYS INC COM 04744L106 11250 3000000 SH SOLE 1 3000000 0 0 AVANIR PHARMACEUTICALS CL A NEW 05348P401 1723 1706138 SH SOLE 1 1706138 0 0 BARR PHARMACEUTICALS INC COM 068306109 45880 949700 SH SOLE 1 949700 0 0 BAXTER INTL INC COM 071813109 91633 1584800 SH SOLE 1 1334800 0 250000 BECKMAN COULTER INC COM 075811109 7423 115000 SH SOLE 0 0 115000 BECTON DICKINSON & CO COM 075887109 9444 110000 SH SOLE 0 0 110000 BIOCRYST PHARMACEUTICALS COM 09058V103 8617 1869231 SH SOLE 1869231 0 0 BIODEL INC COM 09064M105 19666 1812574 SH SOLE 1 1812574 0 0 BIOGEN IDEC INC COM 09062X103 143004 2318100 SH SOLE 1 2058100 0 260000 BIOMARIN PHARMACEUTICAL INC COM 09061G101 89794 2538700 SH SOLE 1 2297200 0 241500 BRISTOL MYERS SQUIBB CO COM 110122108 6390 300000 SH Call SOLE 1 2500 0 297500 BRISTOL MYERS SQUIBB CO COM 110122108 137632 6461600 SH SOLE 1 5561600 0 900000 CALIPER LIFE SCIENCES INC COM 130872104 4368 1164800 SH SOLE 1 484800 0 680000 CELGENE CORP COM 151020104 8103 132200 SH SOLE 132200 0 0 COVANCE INC COM 222816100 3983 48000 SH SOLE 1 0 0 48000 COVIDIEN LTD COM G2552X108 43608 985500 SH SOLE 1 745500 0 240000 CURIS INC COM 231269101 7722 5438311 SH SOLE 1 5438311 0 0 CV THERAPEUTICS INC COM 126667104 5419 760000 SH SOLE 1 574800 0 185200 CYTOGEN CORP COM NEW 232824300 685 1202300 SH SOLE 1 1202300 0 0 CYTOKINETICS INC COM 23282W100 12860 3873600 SH SOLE 1 3873600 0 0 CYTRX CORP COM NEW 232828301 3864 3359800 SH SOLE 1 3359800 0 0 DENDREON CORP COM 24823Q107 4820 1000000 SH Put SOLE 1 7105 0 992895 DISCOVERY LABORATORIES INC N COM 254668106 2820 1200000 SH SOLE 1 1200000 0 0 ELAN PLC ADR 284131208 6258 300000 SH Call SOLE 1 2330 0 297670 ENTEROMEDICS INC COM 29365M109 1877 450000 SH SOLE 0 0 450000 EPIX PHARMACEUTICALS INC COM NEW 26881Q309 736 514906 SH SOLE 1 514906 0 0 EXELIXIS INC COM 30161Q104 34373 4945700 SH SOLE 1 4468700 0 477000 GEN-PROBE INC NEW COM 36866T103 139447 2893100 SH SOLE 1 2643100 0 250000 GENELABS TECHNOLOGIES INC COM NEW 368706206 2418 2717392 SH SOLE 1 2717392 0 0 GENENTECH INC COM NEW 368710406 199329 2455390 SH SOLE 1 2152890 0 302500 GENOMIC HEALTH INC COM 37244C101 23067 1221100 SH SOLE 1 1221100 0 0 GENZYME CORP COM 372917104 217233 2914314 SH SOLE 1 2594314 0 320000 GILEAD SCIENCES INC COM 375558103 73343 1423300 SH SOLE 1 855300 0 568000 GIVEN IMAGING ORD SHS M52020100 5233 310000 SH SOLE 1 50000 0 260000 HANA BIOSCIENCES INC COM 40963P105 667 717246 SH SOLE 717246 0 0 HUMAN GENOME SCIENCES INC COM 444903108 17941 3046000 SH SOLE 1 2296000 0 750000 IMCLONE SYS INC COM 45245W109 98584 2324000 SH SOLE 1 2060100 0 263900 INDEVUS PHARMACEUTICALS INC COM 454072109 25701 5388000 SH SOLE 1 4738000 0 650000 INFINITY PHARMACEUTICALS INC COM 45665G303 2395 402500 SH SOLE 1 402500 0 0 INSULET CORP COM 45784P101 22591 1568819 SH SOLE 1568819 0 0 INTEGRA LIFESCIENCES HLDGS C COM NEW 457985208 4782 110000 SH SOLE 1 0 0 110000 INTERMUNE INC COM 45884X103 59080 4052100 SH SOLE 1 3494100 0 558000 ISHARES TR NASDQ BIO INDX 464287556 60624 800000 SH Put SOLE 1 6500 0 793500 ISHARES TR NASDQ BIO INDX 464287556 18945 250000 SH Call SOLE 1 2000 0 248000 KOSAN BIOSCIENCES INC COM 50064W107 6567 4183100 SH SOLE 1 4183100 0 0 LIFECELL CORP COM 531927101 40408 961400 SH SOLE 1 961400 0 0 MAXYGEN INC COM 577776107 4600 712000 SH SOLE 1 712000 0 0 MEDTRONIC INC COM 585055106 17437 360500 SH SOLE 1 0 0 360500 MERCK & CO INC COM 589331107 53191 1401600 SH SOLE 1 1150200 0 251400 MILLENNIUM PHARMACEUTICALS I COM 599902103 46664 3018400 SH SOLE 1 3018400 0 0 MILLIPORE CORP COM 601073109 3842 57000 SH SOLE 0 0 57000 MYLAN INC COM 628530107 66084 5696900 SH SOLE 1 5069300 0 627600 NEOSE TECHNOLOGIES INC COM 640522108 527 1881000 SH SOLE 1 1881000 0 0 NEUROBIOLOGICAL TECH INC COM NEW 64124W304 1300 500000 SH SOLE 0 0 500000 NEUROGEN CORP COM 64124E106 3666 1971000 SH SOLE 1 1971000 0 0 NPS PHARMACEUTICALS INC COM 62936P103 15450 3961500 SH SOLE 1 3961500 0 0 OMRIX BIOPHARMACEUTICALS INC COM 681989109 10493 749500 SH SOLE 1 594500 0 155000 ONYX PHARMACEUTICALS INC COM 683399109 79786 2748400 SH SOLE 1 2381500 0 366900 OREXIGEN THERAPEUTICS INC COM 686164104 1546 150100 SH SOLE 1 150100 0 0 OSCIENT PHARMACEUTICALS CORP NOTE 3.500% 4/1 68812RAC9 1102 3340000 SH SOLE 1 3340000 0 0 OSI PHARMACEUTICALS INC COM 671040103 79757 2133100 SH SOLE 1 1913100 0 220000 PAR PHARMACEUTICAL COS INC COM 69888P106 42188 2426000 SH SOLE 1 1881000 0 545000 PERRIGO CO COM 714290103 4377 116000 SH SOLE 1 116000 0 0 PFIZER INC COM 717081103 40238 1922500 SH SOLE 1 1922500 0 0 PHARMACOPEIA INC COM 7171EP101 4877 1336300 SH SOLE 1 1336300 0 0 PHARMASSET INC COM 71715N106 1457 80800 SH SOLE 1 80800 0 0 PONIARD PHARMACEUTICALS INC COM NEW 732449301 9228 2754700 SH SOLE 1 2754700 0 0 QLT INC COM 746927102 4012 1130000 SH SOLE 1 797100 0 332900 ROSETTA GENOMICS LTD SHS M82183100 2043 408500 SH SOLE 1 408500 0 0 RXI PHARMACEUTICALS CORP COM 74978T109 899 94601 SH SOLE 1 94601 0 0 SCHERING PLOUGH CORP COM 806605101 116231 8066000 SH SOLE 1 7197800 0 868200 SEPRACOR INC COM 817315104 29100 1490800 SH SOLE 1490800 0 0 SGX PHARMACEUTICALS INC COM 78423C108 3275 2408400 SH SOLE 1 1738400 0 670000 SONOSITE INC COM 83568G104 28220 992600 SH SOLE 1 792600 0 200000 ST JUDE MED INC COM 790849103 6479 150000 SH SOLE 0 0 150000 STRYKER CORP COM 863667101 4228 65000 SH SOLE 0 0 65000 TARGANTA THERAPEUTICS CORP COM 87612C100 14290 1843909 SH SOLE 1 1843909 0 0 TARGETED GENETICS CORP COM NEW 87612M306 1325 1325000 SH SOLE 1 1325000 0 0 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 4499 97400 SH SOLE 1 97400 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 14210 250000 SH SOLE 0 0 250000 TRIMERIS INC COM 896263100 11069 1697700 SH SOLE 1 1697700 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 3217 37100 SH SOLE 1 37100 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 100283 4197700 SH SOLE 1 3751400 0 446300 VIVUS INC COM 928551100 14095 2337500 SH SOLE 1 2337500 0 0 VOLCANO CORPORATION COM 928645100 29571 2365685 SH SOLE 1 2365685 0 0 WATERS CORP COM 941848103 7241 130000 SH SOLE 0 0 130000 WYETH COM 983024100 61913 1482600 SH SOLE 1 1482600 0 0 XOMA LTD ORD G9825R107 37863 14618869 SH SOLE 1 11618869 0 3000000
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