The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   6,324,500 350,000 SH   DFND 1,2 0 350,000 0
ACLARIS THERAPEUTICS INC COM 00461U105   20,134,195 1,941,581 SH   DFND 1,2 0 1,941,581 0
ACLARIS THERAPEUTICS INC COM 00461U105   2,644,350 255,000 SH Put DFND 1,2 0 255,000 0
ACUMEN PHARMACEUTICALS INC COM 00509G209   5,056,594 1,051,267 SH   DFND 1,2 0 1,051,267 0
AEROVATE THERAPEUTICS INC COM 008064107   15,986,510 932,158 SH   DFND 1,2 0 932,158 0
ALKERMES PLC SHS G01767105   12,878,479 411,453 SH   DFND 1,2 0 411,453 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   34,578,713 3,363,688 SH   DFND 1,2 0 3,363,688 0
AMICUS THERAPEUTICS INC COM 03152W109   8,809,484 701,392 SH   DFND 1,2 0 701,392 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   20,896,908 968,795 SH   DFND 1,2 0 968,795 0
ANAPTYSBIO INC COM 032724106   18,190,733 894,333 SH   DFND 1,2 0 894,333 0
APELLIS PHARMACEUTICALS INC COM 03753U106   8,627,170 94,700 SH Put DFND 1,2 0 94,700 0
ARCELLX INC COMMON STOCK 03940C100   1,185,750 37,500 SH   DFND 1,2 0 37,500 0
CYTOKINETICS INC COM NEW 23282W605   19,572,000 600,000 SH   DFND 1,2 0 600,000 0
EVOLUS INC COM 30052C107   17,695,529 2,434,048 SH   DFND 1,2 0 2,434,048 0
GENERATION BIO CO COM 37148K100   5,623,954 1,022,537 SH   DFND 1,2 0 1,022,537 0
GRACELL BIOTECHNOLOGIES INC SPONSORED ADS 38406L103   8,641,297 2,268,057 SH   DFND 1,2 0 2,268,057 0
HERON THERAPEUTICS INC COM 427746102   5,495,347 4,737,368 SH   DFND 1,2 0 4,737,368 0
IGM BIOSCIENCES INC COM 449585108   4,615,000 500,000 SH   DFND 1,2 0 500,000 0
IMMUNOCORE HLDGS PLC ADS 45258D105   17,813,037 297,082 SH   DFND 1,2 0 297,082 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108   6,650,621 601,322 SH   DFND 1,2 0 601,322 0
MERSANA THERAPEUTICS INC COM 59045L106   230,300 70,000 SH Call DFND 1,2 0 70,000 0
MINERALYS THERAPEUTICS INC COM 603170101   9,310,306 546,059 SH   DFND 1,2 0 546,059 0
OPTINOSE INC COM 68404V100   10,873,125 8,839,939 SH   DFND 1,2 0 8,839,939 0
PLIANT THERAPEUTICS INC COM 729139105   28,089,334 1,550,184 SH   DFND 1,2 0 1,550,184 0
POINT BIOPHARMA GLOBAL INC COM 730541109   27,180,000 3,000,000 SH   DFND 1,2 0 3,000,000 0
PRECISION BIOSCIENCES INC COM 74019P108   3,929,081 7,469,736 SH   DFND 1,2 0 7,469,736 0
RAPT THERAPEUTICS INC COM 75382E109   27,398,324 1,465,151 SH   DFND 1,2 0 1,465,151 0
RENEO PHARMACEUTICALS INC COM 75974E103   7,106,560 1,083,317 SH   DFND 1,2 0 1,083,317 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   12,730,280 772,000 SH   DFND 1,2 0 772,000 0
SAREPTA THERAPEUTICS INC COM 803607100   14,154,672 123,600 SH   DFND 1,2 0 123,600 0
SERES THERAPEUTICS INC COM 81750R102   4,493,341 938,067 SH   DFND 1,2 0 938,067 0
SOLID BIOSCIENCES INC COM NEW 83422E204   3,062,560 584,458 SH   DFND 1,2 0 584,458 0
TALARIS THERAPEUTICS INC COM 87410C104   2,024,740 666,033 SH   DFND 1,2 0 666,033 0
TRAVERE THERAPEUTICS INC COM 89422G107   921,600 60,000 SH   DFND 1,2 0 60,000 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108   31,249,661 677,426 SH   DFND 1,2 0 677,426 0
VAXCYTE INC COM 92243G108   29,425,197 589,211 SH   DFND 1,2 0 589,211 0
VIKING THERAPEUTICS INC COM 92686J106   9,702,496 598,550 SH   DFND 1,2 0 598,550 0
XENON PHARMACEUTICALS INC COM 98420N105   20,405,000 530,000 SH   DFND 1,2 0 530,000 0
XENON PHARMACEUTICALS INC COM 98420N105   103,950 2,700 SH Put DFND 1,2 0 2,700 0
ZURA BIO LTD CLASS A ORD SHS G9TY5A101   27,019,000 3,295,000 SH   DFND 1,2 0 3,295,000 0