The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   25,582,500 1,350,000 SH   DFND 1 1,350,000 0 0
AEROVATE THERAPEUTICS INC COM 008064107   26,783,086 1,561,696 SH   DFND 1 1,561,696 0 0
AKERO THERAPEUTICS INC COM 00973Y108   5,369,350 115,000 SH   DFND 1 115,000 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   4,596,713 612,079 SH   DFND 1 612,079 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102   158,281,911 9,616,155 SH   DFND 1 9,616,155 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   119,341,000 1,310,000 SH   DFND 1 1,310,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   3,552,900 39,000 SH Call DFND 1 39,000 0 0
ARCELLX INC COMMON STOCK 03940C100   63,240,000 2,000,000 SH   DFND 1 2,000,000 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   7,624,000 800,000 SH   DFND 1 800,000 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   8,330,000 1,000,000 SH   DFND 1 1,000,000 0 0
ATEA PHARMACEUTICALS INC COM 04683R106   5,786,457 1,547,181 SH   DFND 1 1,547,181 0 0
ATRECA INC CL A COM 04965G109   312,676 319,057 SH   DFND 1 319,057 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   933,357 392,167 SH   DFND 1 392,167 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   28,968,355 2,612,115 SH   DFND 1 2,612,115 0 0
AXONICS INC COM 05465P101   16,263,453 322,240 SH   DFND 1 322,240 0 0
AXSOME THERAPEUTICS INC COM 05464T104   24,432,400 340,000 SH   DFND 1 340,000 0 0
BIOATLA INC COM 09077B104   3,543,345 1,181,115 SH   DFND 1 1,181,115 0 0
BIOHAVEN LTD COM G1110E107   1,960,555 81,963 SH   DFND 1 81,963 0 0
BIOMEA FUSION INC COM 09077A106   78,380,646 3,570,872 SH   DFND 1 3,570,872 0 0
BRIDGEBIO PHARMA INC COM 10806X102   71,709,879 4,169,179 SH   DFND 1 4,169,179 0 0
BRIDGEBIO PHARMA INC COM 10806X102   13,945,760 810,800 SH Put DFND 1 810,800 0 0
CABALETTA BIO INC COM 12674W109   28,682,650 2,221,739 SH   DFND 1 2,221,739 0 0
CENTESSA PHARMACEUTICALS PLC SPONSORED ADS 152309100   3,476,304 561,600 SH   DFND 1 561,600 0 0
COGENT BIOSCIENCES INC COM 19240Q201   11,840,000 1,000,000 SH   DFND 1 1,000,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   41,610,000 3,800,000 SH   DFND 1 3,800,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103   32,445,000 5,150,000 SH   DFND 1 5,150,000 0 0
DISC MEDICINE INC COM 254604101   9,990,000 225,000 SH   DFND 1 225,000 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   22,838,374 2,946,887 SH   DFND 1 2,946,887 0 0
ENLIVEN THERAPEUTICS INC COM 29337E102   39,516,475 1,936,133 SH   DFND 1 1,936,133 0 0
ERASCA INC COM 29479A108   29,844,559 10,813,246 SH   DFND 1 10,813,246 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   27,840,000 3,200,000 SH   DFND 1 3,200,000 0 0
GALECTO INC COM 36322Q107   2,571,000 1,020,238 SH   DFND 1 1,020,238 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106   7,036,455 593,043 SH   DFND 1 593,043 0 0
GRAPHITE BIO INC COM 38870X104   518,822 199,547 SH   DFND 1 199,547 0 0
GREENLIGHT BIOSCIENCS HLDS P COMMON STOCK 39536G105   2,739,139 9,188,659 SH   DFND 1 9,188,659 0 0
HARPOON THERAPEUTICS INC COM 41358P106   383,826 540,600 SH   DFND 1 540,600 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   14,100,000 600,000 SH   DFND 1 600,000 0 0
IMMUNEERING CORP CLASS A COM 45254E107   42,632,251 4,204,364 SH   DFND 1 4,204,364 0 0
IMMUNOVANT INC COM 45258J102   10,433,500 550,000 SH   DFND 1 550,000 0 0
IVERIC BIO INC COM 46583P102   11,802,000 300,000 SH Call DFND 1 300,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100   17,348,000 80,000 SH   DFND 1 80,000 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   3,358,634 1,073,046 SH   DFND 1 1,073,046 0 0
LIANBIO SPONSORED ADS 53000N108   9,690,000 4,250,000 SH   DFND 1 4,250,000 0 0
LONGBOARD PHARMACEUTICALS IN COM 54300N103   17,272,055 2,353,141 SH   DFND 1 2,353,141 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   415,247,100 8,142,100 SH   DFND 1 8,142,100 0 0
MORPHIC HLDG INC COM 61775R105   8,599,500 150,000 SH   DFND 1 150,000 0 0
OCULAR THERAPEUTIX INC COM 67576A100   3,328,200 645,000 SH   DFND 1 645,000 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   27,830,460 3,082,000 SH   DFND 1 3,082,000 0 0
ORCHARD THERAPEUTICS PLC SPON ADS NEW 68570P200   133,709 25,664 SH   DFND 1 25,664 0 0
PHARVARIS N V COM N69605108   14,740,516 973,614 SH   DFND 1 973,614 0 0
PRAXIS PRECISION MEDICINES I COM 74006W108   10,925,000 9,500,000 SH   DFND 1 9,500,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   41,430,000 1,500,000 SH   DFND 1 1,500,000 0 0
RAPT THERAPEUTICS INC COM 75382E109   6,077,500 325,000 SH   DFND 1 325,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   9,894,000 600,000 SH   DFND 1 600,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   17,258,089 868,550 SH   DFND 1 868,550 0 0
SAREPTA THERAPEUTICS INC COM 803607100   14,887,600 130,000 SH   DFND 1 130,000 0 0
STOKE THERAPEUTICS INC COM 86150R107   11,563,388 1,087,807 SH   DFND 1 1,087,807 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   23,959,826 576,373 SH   DFND 1 576,373 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   25,685,096 1,421,422 SH   DFND 1 1,421,422 0 0
VAXCYTE INC COM 92243G108   33,210,100 665,000 SH   DFND 1 665,000 0 0
VERVE THERAPEUTICS INC COM 92539P101   6,562,500 350,000 SH   DFND 1 350,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   5,797,788 616,786 SH   DFND 1 616,786 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   20,221,500 850,000 SH   DFND 1 850,000 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107   30,889,950 1,095,000 SH   DFND 1 1,095,000 0 0