The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 5,293 5,600 SH   SOLE 1 5,600 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102 BBG00ZHF9WP3 65,380 69,169 SH   SOLE   69,169 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 7,093 2,015 SH   SOLE 1 2,015 0 0
ANNEXON INC COM 03589W102 BBG007QVDFH1 87,209 24,775 SH   SOLE   24,775 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 56,671 19,210 SH   SOLE   19,210 0 0
ATHIRA PHARMA INC COM 04746L104 BBG00C77LXM0 4,720 1,600 SH   SOLE 1 1,600 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 1,112,946 36,407 SH   SOLE   36,407 0 0
BARCLAYS BANK PLC DJUBS CMDT ETN36 06738C778 BBG001SPJ625 184,520 6,036 SH   SOLE 1 6,036 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 6,364 3,700 SH   SOLE 1 3,700 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 BBG001V0GS49 78,942 45,896 SH   SOLE   45,896 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 1,223,713 34,597 SH   SOLE 1 34,597 0 0
DBX ETF TR XTRACK MSCI EAFE 233051200 BBG001S9Z3V8 4,886,940 138,164 SH   SOLE   138,164 0 0
DEERE & CO COM 244199105 BBG001S5QFF7 443,262 1,094 SH   SOLE 1 1,094 0 0
DEERE & CO COM 244199105 BBG001S5QFF7 1,621 4 SH   SOLE   4 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 926,377 34,310 SH   SOLE 1 34,310 0 0
FIRST TR EXCHANGE-TRADED FD NO AMER ENERGY 33738D101 BBG0034YTRP6 4,280,378 158,531 SH   SOLE   158,531 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 BBG00V9VQ4K4 7,005 1,500 SH   SOLE 1 1,500 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 BBG00V9VQ4K4 86,748 18,575 SH   SOLE   18,575 0 0
GERON CORP COM 374163103 BBG001S6TSX4 44,271 13,791 SH   SOLE   13,791 0 0
GERON CORP COM 374163103 BBG001S6TSX4 3,531 1,100 SH   SOLE 1 1,100 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 16,496 265 SH   SOLE 1 265 0 0
INCYTE CORP COM 45337C102 BBG001S8Q6N2 203,435 3,268 SH   SOLE   3,268 0 0
INVESCO EXCH TRADED FD TR II S&P GBL WATER 46138E263 BBG00KJR22S8 44,626 868 SH   SOLE   868 0 0
INVESCO EXCH TRADED FD TR II S&P GBL WATER 46138E263 BBG00KJR22S8 416,215 8,096 SH   SOLE 1 8,096 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 190,045 9,033 SH   SOLE 1 9,033 0 0
INVESCO EXCH TRADED FD TR II SR LN ETF 46138G508 BBG001V0MBC0 2,043,724 97,138 SH   SOLE   97,138 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 112,088 6,919 SH   SOLE 1 6,919 0 0
INVESCO EXCH TRD SLF IDX FD INVSCO 30 CORP 46138J460 BBG00X3HYBX8 588,113 36,303 SH   SOLE   36,303 0 0
INVESCO EXCHANGE TRADED FD T DWA MOMENTUM 46137V837 BBG001SJ09N0 1,569,947 19,375 SH   SOLE   19,375 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 1,796,834 73,221 SH   SOLE   73,221 0 0
ISHARES INC CUR HD MSCI EM 46434G509 BBG0076SN965 3,668 149 SH   SOLE 1 149 0 0
ISHARES INC ESG AWR MSCI EM 46434G863 BBG00D7BDH70 26,424 835 SH   SOLE   835 0 0
ISHARES INC ESG AWR MSCI EM 46434G863 BBG00D7BDH70 236,118 7,465 SH   SOLE 1 7,465 0 0
ISHARES TR 0-5 YR TIPS ETF 46429B747 BBG001TG5H89 2,090,197 21,416 SH   SOLE   21,416 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 525,428 5,104 SH   SOLE   5,104 0 0
ISHARES TR 20 YR TR BD ETF 464287432 BBG001S8MLN3 90,484 879 SH   SOLE 1 879 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 1,449,116 12,573 SH   SOLE 1 12,573 0 0
ISHARES TR 3 7 YR TREAS BD 464288661 BBG001SSD812 704,419 6,109 SH   SOLE   6,109 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 1,490,428 15,429 SH   SOLE 1 15,429 0 0
ISHARES TR 7-10 YR TRSY BD 464287440 BBG001S80936 856,493 8,864 SH   SOLE   8,864 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 347,000 3,443 SH   SOLE 1 3,443 0 0
ISHARES TR CORE HIGH DV ETF 46429B663 BBG001V0XLT8 5,396,320 53,539 SH   SOLE   53,539 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 35,317 79 SH   SOLE 1 79 0 0
ISHARES TR CORE S&P500 ETF 464287200 BBG001SFB7R6 2,822,487 6,334 SH   SOLE   6,334 0 0
ISHARES TR ESG AW MSCI EAFE 46435G516 BBG00D7BBRS7 24,995,084 342,725 SH   SOLE   342,725 0 0
ISHARES TR ESG AW MSCI EAFE 46435G516 BBG00D7BBRS7 641,308 8,793 SH   SOLE 1 8,793 0 0
ISHARES TR FLTG RATE NT ETF 46429B655 BBG001V1QYX1 1,039,324 20,451 SH   SOLE   20,451 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 1,419,897 30,243 SH   SOLE 1 30,243 0 0
ISHARES TR GLB INFRASTR ETF 464288372 BBG001SYVWT6 5,670,149 120,773 SH   SOLE   120,773 0 0
ISHARES TR GLOBAL REIT ETF 46434V647 BBG006S5D3J3 340,596 14,828 SH   SOLE   14,828 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 2,816,531 26,043 SH   SOLE   26,043 0 0
ISHARES TR IBOXX INV CP ETF 464287242 BBG001S60QR6 97,625 903 SH   SOLE 1 903 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 2,476,933 28,621 SH   SOLE   28,621 0 0
ISHARES TR JPMORGAN USD EMG 464288281 BBG001SQS9Y2 12,339 143 SH   SOLE 1 143 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 1,589,367 17,041 SH   SOLE   17,041 0 0
ISHARES TR MBS ETF 464288588 BBG001SSD8B1 167,756 1,799 SH   SOLE 1 1,799 0 0
ISHARES TR MSCI USA MIN VOL 46429B697 BBG0025X2G81 770,746 10,370 SH   SOLE   10,370 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 10,972,935 76,067 SH   SOLE   76,067 0 0
ISHARES TR MSCI USA MMENTM 46432F396 BBG004FPV022 2,915,536 20,211 SH   SOLE 1 20,211 0 0
ISHARES TR SHORT TREAS BD 464288679 BBG001SSD803 1,334,227 12,080 SH   SOLE   12,080 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 1,494,364 13,885 SH   SOLE   13,885 0 0
ISHARES TR TIPS BD ETF 464287176 BBG001SD9RM5 692,094 6,431 SH   SOLE 1 6,431 0 0
JASPER THERAPEUTICS INC COM 471871103 BBG00QPZNPB4 87,910 64,167 SH   SOLE   64,167 0 0
JASPER THERAPEUTICS INC COM 471871103 BBG00QPZNPB4 7,124 5,200 SH   SOLE 1 5,200 0 0
JPMORGAN CHASE & CO COM 46625H100 BBG001S8CRC3 500,062 3,438 SH   SOLE 1 3,438 0 0
JPMORGAN CHASE & CO COM 46625H100 BBG001S8CRC3 1,758 12 SH   SOLE   12 0 0
KRONOS BIO INC COM 50107A104 BBG00L072932 4,988 2,900 SH   SOLE 1 2,900 0 0
KRONOS BIO INC COM 50107A104 BBG00L072932 62,209 36,168 SH   SOLE   36,168 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 16,163 183 SH   SOLE 1 183 0 0
MEDTRONIC PLC SHS G5960L103 BBG001S5T2S9 198,050 2,248 SH   SOLE   2,248 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 8,184 6,200 SH   SOLE 1 6,200 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 101,045 76,549 SH   SOLE   76,549 0 0
NKARTA INC COM 65487U108 BBG00JXHS9H6 20,953 9,567 SH   SOLE   9,567 0 0
NKARTA INC COM 65487U108 BBG00JXHS9H6 1,752 800 SH   SOLE 1 800 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 1,692 4 SH   SOLE   4 0 0
NVIDIA CORPORATION COM 67066G104 BBG001S5TZJ6 733,293 1,733 SH   SOLE 1 1,733 0 0
PFIZER INC COM 717081103 BBG001S5V466 262,408 7,152 SH   SOLE   7,152 0 0
PFIZER INC COM 717081103 BBG001S5V466 21,395 583 SH   SOLE 1 583 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 3,168,582 52,775 SH   SOLE 1 52,775 0 0
PIMCO ETF TR 15+ YR US TIPS 72201R304 BBG001T5HFW7 7,113,319 118,476 SH   SOLE   118,476 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 43,418 24,669 SH   SOLE   24,669 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 BBG00BNTZ9J8 3,432 1,950 SH   SOLE 1 1,950 0 0
PROSHARES TR PSHS ULTRUSS2000 74347R842 BBG001S5RN32 498,570 14,493 SH   SOLE   14,493 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 225,620 314 SH   SOLE   314 0 0
REGENERON PHARMACEUTICALS COM 75886F107 BBG001S6PX49 19,401 27 SH   SOLE 1 27 0 0
SCHWAB STRATEGIC TR US SML CAP ETF 808524607 BBG001T5XQW5 451,480 10,308 SH   SOLE   10,308 0 0
SELECT SECTOR SPDR TR RL EST SEL SEC 81369Y860 BBG00B597137 1,037,835 27,537 SH   SOLE   27,537 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 BBG001S72SM3 8,759,699 19,761 SH   SOLE   19,761 0 0
SPDR SER TR BLOOMBERG HIGH Y 78468R622 BBG001SQS7X7 290,175 3,153 SH   SOLE   3,153 0 0
SPDR SER TR BLOOMBERG INVT 78468R200 BBG0029J2J00 1,864,380 60,749 SH   SOLE   60,749 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 4,318,313 103,407 SH   SOLE   103,407 0 0
SPDR SER TR FTSE INT GVT ETF 78464A490 BBG001STK554 1,107,877 26,530 SH   SOLE 1 26,530 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 BBG001S5WS08 206,368 395 SH   SOLE   395 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 BBG001S5WS08 16,749 32 SH   SOLE 1 32 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 419,384 21,809 SH   SOLE   21,809 0 0
TIDAL ETF TR RPAR RISK PARI 886364603 BBG00R24NZQ8 7,234 376 SH   SOLE 1 376 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 281,946 584 SH   SOLE   584 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 21,964 46 SH   SOLE 1 46 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 1,365,256 27,930 SH   SOLE   27,930 0 0
VANGUARD CHARLOTTE FDS TOTAL INT BD ETF 92203J407 BBG004N1LGK2 142,505 2,915 SH   SOLE 1 2,915 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 47,044 563 SH   SOLE 1 563 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 BBG001SMD2X3 4,582,230 54,839 SH   SOLE   54,839 0 0
VANGUARD INDEX FDS SMALL CP ETF 922908751 BBG001SHTTV0 2,259,687 11,361 SH   SOLE   11,361 0 0
VANGUARD INDEX FDS VALUE ETF 922908744 BBG001SHVR78 1,554,273 10,937 SH   SOLE   10,937 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 1,247,717 30,672 SH   SOLE 1 30,672 0 0
VANGUARD INTL EQUITY INDEX F FTSE EMR MKT ETF 922042858 BBG001SHTTZ6 13,719,712 337,259 SH   SOLE   337,259 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 3,014,305 75,000 SH   SOLE   75,000 0 0
VANGUARD INTL EQUITY INDEX F GLB EX US ETF 922042676 BBG001TCVT65 153,003 3,807 SH   SOLE 1 3,807 0 0
VANGUARD TAX-MANAGED FDS VAN FTSE DEV MKT 921943858 BBG001SSPWL4 12,448,545 269,566 SH   SOLE   269,566 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 233,670 3,753 SH   SOLE   3,753 0 0
VANGUARD WHITEHALL FDS EM MK GOV BD ETF 921946885 BBG004N1LYJ5 143,906 2,311 SH   SOLE 1 2,311 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 4,568,857 52,474 SH   SOLE   52,474 0 0
VANGUARD WORLD FD EXTENDED DUR 921910709 BBG001SV5CV2 412,810 4,741 SH   SOLE 1 4,741 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 187,472 4,184 SH   SOLE 1 4,184 0 0
WISDOMTREE TR US SMALLCAP FUND 97717W562 BBG001SSZBC9 1,322,504 29,513 SH   SOLE   29,513 0 0