The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   4,889,985 481,677 SH   DFND   481,677 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   18,616,958 17,079,779 SH   DFND   17,079,779 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107   1,112,792 5,648,690 SH   DFND   5,648,690 0 0
AFFIMED NV COM N01045108   3,300,389 4,426,488 SH   DFND   4,426,488 0 0
AIRSPAN NETWORKS HOLDINGS INC COM 00951K104   941,419 1,359,842 SH   DFND   1,359,842 0 0
AIRSPAN NETWORKS HOLDINGS INC *W EXP 08/13/2023 00951K138   30 69,928 SH   DFND   69,928 0 0
AIRSPAN NETWORKS HOLDINGS INC *W EXP 08/13/2023 00951K120   67 69,928 SH   DFND   69,928 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108   82,159 452,167 SH   DFND   452,167 0 0
ALLAKOS INC COM 01671P100   27,355,307 6,147,260 SH   DFND   6,147,260 0 0
ARCELLX INC COMMON STOCK 03940C100   146,201,522 4,745,262 SH   DFND   4,745,262 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   43,509,381 3,969,834 SH   DFND   3,969,834 0 0
BERKSHIRE GREY INC COM CL A 084656107   52,692,572 38,183,023 SH   DFND   38,183,023 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105   6,518,151 3,448,757 SH   DFND   3,448,757 0 0
BRIGHT HEALTH GROUP INC COM 10920V107   48,059,242 218,153,623 SH   DFND   218,153,623 0 0
BUZZFEED INC CLASS A COM 12430A102   17,327,298 15,333,892 SH   DFND   15,333,892 0 0
CELCUITY INC COM 15102K100   12,812,510 1,250,001 SH   DFND   1,250,001 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307   6,889,154 1,713,720 SH   DFND   1,713,720 0 0
CLOUDFLARE INC CL A COM 18915M107   77,026,597 1,249,215 SH   DFND   1,249,215 0 0
COURSERA INC COM 22266M104   148,236,699 12,867,769 SH   DFND   12,867,769 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   71,818,636 1,587,854 SH   DFND   1,587,854 0 0
CTI BIOPHARMA CORP COM 12648L601   15,479,869 3,685,683 SH   DFND   3,685,683 0 0
CVRX INC COM 126638105   22,093,452 2,370,542 SH   DFND   2,370,542 0 0
DESKTOP METAL INC COM CL A 25058X105   33,117,532 14,398,927 SH   DFND   14,398,927 0 0
EARGO INC COM NEW 270087208   1,057,680 226,000 SH   DFND   226,000 0 0
FISCALNOTE HOLDINGS INC COM CL A 337655104   576,166 307,344 SH   DFND   307,344 0 0
GERON CORP COM 374163103   46,324,808 21,347,838 SH   DFND   21,347,838 0 0
GLYCOMIMETICS INC COM 38000Q102   6,003,194 4,764,440 SH   DFND   4,764,440 0 0
GOSSAMER BIO INC COM 38341P102   4,368,932 3,467,406 SH   DFND   3,467,406 0 0
INOZYME PHARMA INC COM 45790W108   13,967,958 2,437,689 SH   DFND   2,437,689 0 0
INVENTIVA SA ADS 46124U107   4,993,269 1,462,586 SH   DFND   1,462,586 0 0
IONQ INC COM 46222L108   89,881,198 14,614,829 SH   DFND   14,614,829 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   5,788,955 2,382,286 SH   DFND   2,382,286 0 0
MARKER THERAPEUTICS INC COM NEW 57055L206   760,714 1,071,428 SH   DFND   1,071,428 0 0
MINERVA SURGICAL INC COM 60343F106   6,803,040 34,437,052 SH   DFND   34,437,052 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   100,553,557 4,186,243 SH   DFND   4,186,243 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   59,923,001 7,692,298 SH   DFND   7,692,298 0 0
NEXTNAV INC COMMON STOCK 65345N106   16,623,987 8,189,156 SH   DFND   8,189,156 0 0
NKARTA INC COM 65487U108   12,669,173 3,568,781 SH   DFND   3,568,781 0 0
OBSEVA SA COM H5861P103   499,935 4,586,563 SH   DFND   4,586,563 0 0
PALO ALTO NETWORKS INC COM 697435105   15,580 78 SH   DFND   78 0 0
REGULUS THERAPEUTICS INC COM 75915K200   1,224,734 1,445,114 SH   DFND   1,445,114 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   28,617,254 4,785,494 SH   DFND   4,785,494 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   51,913,615 2,909,956 SH   DFND   2,909,956 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107   1,602,425 2,294,095 SH   DFND   2,294,095 0 0
SAVARA INC COM 805111101   47,068,965 24,137,931 SH   DFND   24,137,931 0 0
SENTI BIOSCIENCES INC COM 81726A100   4,921,682 4,700,385 SH   DFND   4,700,385 0 0
SYNLOGIC INC COM 87166L100   2,672,690 4,228,940 SH   DFND   4,228,940 0 0
TREVI THERAPEUTICS INC COM 89532M101   21,035,196 11,370,376 SH   DFND   11,370,376 0 0
TUYA INC SPONSERED ADS 90114C107   9,326,470 4,934,640 SH   DFND   4,934,640 0 0
VERONA PHARMA PLC SPONSERED ADS 925050106   112,141,840 5,584,753 SH   DFND   5,584,753 0 0
WHEELS UP EXPERIENCE INC COM CL A 96328L106   681,563 1,108,371 SH   DFND   1,108,371 0 0
X4 PHARMACEUTICALS INC COM 98420X103   10,211,010 11,736,793 SH   DFND   11,736,793 0 0
ZEROFOX HLDGS INC COM 98955G103   26,380,029 18,068,513 SH   DFND   18,068,513 0 0