The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCURAY INC COM 004397105   3,630,403 1,222,358 SH   SOLE   1,222,358 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   649,068 51,148 SH   SOLE   51,148 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   382,660 351,064 SH   SOLE   351,064 0 0
ADICET BIO INC COM 007002108   4,591,031 797,054 SH   SOLE   797,054 0 0
ALECTOR INC COM 014442107   3,667,191 592,438 SH   SOLE   592,438 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   3,808,926 57,746 SH   SOLE   57,746 0 0
ARCUS BIOSCIENCES INC COM 03969F109   3,195,958 175,217 SH   SOLE   175,217 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   14,497,431 135,212 SH   SOLE   135,212 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   929,444 69,883 SH   SOLE   69,883 0 0
ATRICURE INC COM 04963C209   5,203,177 125,529 SH   SOLE   125,529 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   2,164,116 1,176,150 SH   SOLE   1,176,150 0 0
AXOGEN INC COM 05463X106   3,138,373 332,103 SH   SOLE   332,103 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   2,599,194 122,200 SH   SOLE   122,200 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   4,599,510 551,500 SH   SOLE   551,500 0 0
BIOHAVEN LTD COM G1110E107   3,218,474 235,613 SH   SOLE   235,613 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   11,752,963 261,235 SH   SOLE   261,235 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106   831,837 473,981 SH   SOLE   473,981 0 0
CARDIOVASCULAR SYSTEMS COM 141619106   5,699,582 286,988 SH   SOLE   286,988 0 0
CENTURY THERAPEUTICS INC COM 15673T100   4,536,702 1,307,407 SH   SOLE   1,307,407 0 0
COMPASS THERAPEUTICS INC COM 20454B104   382,204 116,882 SH   SOLE   116,882 0 0
COMPUGEN LTD ORD M25722105   144,052 205,202 SH   SOLE   205,202 0 0
CYTOKINETICS INC COM NEW 23282W605   9,729,859 276,495 SH   SOLE   276,495 0 0
DEXCOM INC COM 252131107   7,848,191 67,552 SH   SOLE   67,552 0 0
DICE THERAPEUTICS INC COM 23345J104   5,374,310 187,585 SH   SOLE   187,585 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   4,890,704 733,239 SH   SOLE   733,239 0 0
GALAPAGOS NV SPON ADR 36315X101   2,035,362 52,675 SH   SOLE   52,675 0 0
GENFIT S A ADS 372279109   811,554 197,940 SH   SOLE   197,940 0 0
IDEAYA BIOSCIENCES INC COM 45166A102   6,430,555 468,358 SH   SOLE   468,358 0 0
IKENA ONCOLOGY INC COM 45175G108   389,629 112,936 SH   SOLE   112,936 0 0
INOGEN INC COM 45780L104   187,200 15,000 SH   SOLE   15,000 0 0
ISHARES NASDAQ BIOTECH INDX ETF 464287556   13,238,900 102,500 SH   SOLE   102,500 0 0
ITEOS THERAPEUTICS INC COM 46565G104   1,341,402 98,560 SH   SOLE   98,560 0 0
IVERIC BIO INC COM 46583P102   14,913,682 612,975 SH   SOLE   612,975 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   4,842,012 616,032 SH   SOLE   616,032 0 0
KARUNA THERAPEUTICS INC COM 48576A100   14,272,000 78,573 SH   SOLE   78,573 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106   749,517 192,678 SH   SOLE   192,678 0 0
KEROS THERAPEUTICS INC COM 492327101   826,715 19,361 SH   SOLE   19,361 0 0
KINNATE BIOPHARMA INC COM 49705R105   506,300 81,008 SH   SOLE   81,008 0 0
KURA ONCOLOGY INC COM 50127T109   1,342,658 109,784 SH   SOLE   109,784 0 0
LARIMAR THERAPEUTICS INC COM 517125100   1,073,035 236,873 SH   SOLE   236,873 0 0
LINEAGE CELL THERAPEUTICS IN COM 53566P109   210,000 140,000 SH   SOLE   140,000 0 0
MASIMO CORP COM 574795100   553,620 3,000 SH   SOLE   3,000 0 0
MEDICENNA THERAPEUTICS CORP COM 58490H107   415,536 660,000 SH   SOLE   660,000 0 0
MEDIWOUND LTD SHS NEW M68830112   3,431,938 257,653 SH   SOLE   257,653 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107   775,125 1,096,513 SH   SOLE   1,096,513 0 0
MERSANA THERAPEUTICS INC COM 59045L106   2,099,647 510,863 SH   SOLE   510,863 0 0
MERUS N V COM N5749R100   5,225,563 283,998 SH   SOLE   283,998 0 0
MIRATI THERAPEUTICS INC COM 60468T105   2,736,448 73,600 SH   SOLE   73,600 0 0
MORPHIC HOLDING INC COM 61775R105   6,755,138 179,467 SH   SOLE   179,467 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   7,552,530 74,615 SH   SOLE   74,615 0 0
NEURONETICS INC COM 64131A105   912,916 313,717 SH   SOLE   313,717 0 0
NEXTCURE INC COM 65343E108   277,790 187,696 SH   SOLE   187,696 0 0
NURIX THERAPEUTICS INC COM 67080M103   5,032,252 566,695 SH   SOLE   566,695 0 0
ORIC PHARMACEUTICALS INC COM 68622P109   970,858 170,326 SH   SOLE   170,326 0 0
PARDES BIOSCIENCES INC COM 69945Q105   632,790 479,386 SH   SOLE   479,386 0 0
PROQR THERAPEUTICS N V SHS EURO N71542109   2,003,440 940,582 SH   SOLE   940,582 0 0
REGULUS THERAPEUTICS INC COM 75915K309   470,833 555,555 SH   SOLE   555,555 0 0
REUNION NEUROSCIENCE INC COM 76134G103   8,698 12,598 SH   SOLE   12,598 0 0
REVOLUTION MEDICINES INC COM 76155X100   12,471,503 575,785 SH   SOLE   575,785 0 0
SAGE THERAPEUTICS INC COM 78667J108   7,565,640 180,306 SH   SOLE   180,306 0 0
SPDR S&P BIOTECH ETF ETF 78464A870   43,439,700 570,000 SH   SOLE   570,000 0 0
SPERO THERAPEUTICS INC COM 84833T103   181,250 125,000 SH   SOLE   125,000 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   689,520 312,000 SH   SOLE   312,000 0 0
STEREOTAXIS INC COM NEW 85916J409   27,908,330 13,680,554 SH   SOLE   13,680,554 0 0
SURFACE ONCOLOGY INC COM 86877M209   768,680 1,100,000 SH   SOLE   1,100,000 0 0
SUTRO BIOPHARMA INC COM 869367102   391,314 84,700 SH   SOLE   84,700 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105   9,442,182 447,073 SH   SOLE   447,073 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   709,894 265,878 SH   SOLE   265,878 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101   1,163,502 131,025 SH   SOLE   131,025 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   1,686,895 172,308 SH   SOLE   172,308 0 0
VIKING THERAPEUTICS INC COM 92686J106   5,313,931 319,155 SH   SOLE   319,155 0 0
XENON PHARMACEUTICALS INC COM 98420N105   11,312,933 316,092 SH   SOLE   316,092 0 0