The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   12,033,000 700,000 SH   SOLE   700,000 0 0
ABCELLERA BIOLOGICS INC COM 00288U106   8,496,939 1,126,915 SH   SOLE   1,126,915 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   51,174,503 500,827 SH   SOLE   500,827 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   23,714,483 118,383 SH   SOLE   118,383 0 0
AMICUS THERAPEUTICS INC COM 03152W109   23,243,531 2,095,900 SH   SOLE   2,095,900 0 0
ARCELLX, INC. COMMON STOCK 03940C100   37,742,250 1,225,000 SH   SOLE   1,225,000 0 0
APPLE INC COM 037833100   48,691,672 295,280 SH   SOLE   295,280 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   154,364,607 226,770 SH   SOLE   226,770 0 0
BELLUS HEALTH INC. COM NEW 07987C204   15,393,420 2,137,975 SH   SOLE   2,137,975 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   35,724,031 367,380 SH   SOLE   367,380 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   20,191,692 448,804 SH   SOLE   448,804 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104   82,088,918 2,508,830 SH   SOLE   2,508,830 0 0
CABLE ONE INC COM 12685J105   66,060,306 94,103 SH   SOLE   94,103 0 0
CATALENT INC COM 148806102   54,728,413 832,878 SH   SOLE   832,878 0 0
CORCEPT THERAPEUTICS INC COM 218352102   73,162,455 3,377,768 SH   SOLE   3,377,768 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   17,666,000 1,100,000 SH   SOLE   1,100,000 0 0
CYTEIR THERAPEUTICS INC COM 23284P103   112,892,832 3,940,413 SH   SOLE   3,940,413 0 0
DICE THERAPEUTICS, INC. COM 23345J104   16,726,320 536,100 SH   SOLE   536,100 0 0
DISC MEDICINE, INC. COM 254604101   49,600,959 2,340,772 SH   SOLE   2,340,772 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   40,498,259 6,071,703 SH   SOLE   6,071,703 0 0
GALECTO INC COM 36322Q107   4,970,604 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108   6,295,094 2,459,021 SH   SOLE   2,459,021 0 0
INARI MED INC COM 45332Y109   11,113,200 180,000 SH   SOLE   180,000 0 0
INSMED INC COM PAR $.01 457669307   22,835,133 1,339,304 SH   SOLE   1,339,304 0 0
INSPIRE MED SYS INC COM 457730109   14,044,200 60,000 SH   SOLE   60,000 0 0
IO BIOTECH INC COM 449778109   6,146,123 3,277,932 SH   SOLE   3,277,932 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   1,457,341 465,604 SH   SOLE   465,604 0 0
KINNATE BIOPHARMA INC COM 49705R105   5,098,169 815,707 SH   SOLE   815,707 0 0
LANZATECH GLOBAL INC COM 51655R101   61,361,599 15,814,845 SH   SOLE   15,814,845 0 0
LAVA THERAPEUTICS NV SHS N51517105   5,097,126 3,070,558 SH   SOLE   3,070,558 0 0
MARQETA INC CLASS A COM 57142B104   2,017,920 441,558 SH   SOLE   441,558 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   40,454,316 1,684,193 SH   SOLE   1,684,193 0 0
PHARVARIS N V COM N69605108   10,714,360 1,329,325 SH   SOLE   1,329,325 0 0
PULMONX CORP COM 745848101   5,708,005 510,555 SH   SOLE   510,555 0 0
RALLYBIO CORP COM 75120L100   12,962,328 2,270,110 SH   SOLE   2,270,110 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   20,513,654 3,430,377 SH   SOLE   3,430,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   15,759,600 920,000 SH   SOLE   920,000 0 0
SALESFORCE.COM, INC. COM 79466L302   115,572,730 578,500 SH   SOLE   578,500 0 0
SEAGEN INC. COM 81181C104   27,330,615 134,986 SH   SOLE   134,986 0 0
SILK RD MED INC COM 82710M100   10,780,745 275,511 SH   SOLE   275,511 0 0
SPERO THERAPEUTICS INC COM 84833T103   679,908 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   14,856,363 6,722,336 SH   SOLE   6,722,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   66,116,756 710,780 SH   SOLE   710,780 0 0
TREACE MED CONCEPTS INC COM 89455T109   13,602,600 540,000 SH   SOLE   540,000 0 0
VAXCYTE INC COM 92243G108   27,922,600 745,000 SH   SOLE   745,000 0 0
VECTIVBIO HLDG AG ORD SHS H9060V101   30,725,023 3,610,461 SH   SOLE   3,610,461 0 0
VERVE THERAPEUTICS INC COM 92539P101   17,304,000 1,200,000 SH   SOLE   1,200,000 0 0