The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89bio Inc EQUITIES 282559103   6,674,014 438,215 SH   SOLE   438,215 0 0
89bio, Inc LONG OPTION CALLS 282559103   3,046,000 200,000 SH Call SOLE   200,000 0 0
Aclaris Therapeutics Inc EQUITIES 00461U105   1,780,609 220,100 SH   SOLE   220,100 0 0
Aclaris Therapeutics, Inc LONG OPTION CALLS 00461U105   5,269,826 651,400 SH Call SOLE   651,400 0 0
Acumen Pharmaceuticals Inc EQUITIES 00509G209   596,503 146,922 SH   SOLE   146,922 0 0
Akero Therapeutics Inc EQUITIES 00973Y108   7,749,984 202,561 SH   SOLE   202,561 0 0
Aligos Therapeutics Inc EQUITIES 01626L105   552,269 631,887 SH   SOLE   631,887 0 0
Allakos Inc EQUITIES 01671P100   938,995 211,010 SH   SOLE   211,010 0 0
Alnylam Pharmaceuticals Inc EQUITIES 02043Q107   2,813,094 14,043 SH   SOLE   14,043 0 0
Altimmune, Inc LONG OPTION CALLS 02155H200   1,754,254 415,700 SH Call SOLE   415,700 0 0
Astria Therapeutics Inc EQUITIES 04635X102   1,247,846 93,823 SH   SOLE   93,823 0 0
Bellus Health Inc EQUITIES 07987C204   7,200,000 1,000,000 SH   SOLE   1,000,000 0 0
BioCryst Pharmaceuticals Inc EQUITIES 09058V103   4,818,493 577,757 SH   SOLE   577,757 0 0
Biogen Idec Inc EQUITIES 09062X103   3,144,797 11,311 SH   SOLE   11,311 0 0
Bridgebio Pharma Inc EQUITIES 10806X102   663,200 40,000 SH   SOLE   40,000 0 0
Celldex Therapeutics Inc EQUITIES 15117B202   3,045,743 84,651 SH   SOLE   84,651 0 0
Cerus Corp EQUITIES 157085101   3,424,119 1,152,902 SH   SOLE   1,152,902 0 0
Cogent Biosciences Inc EQUITIES 19240Q201   6,250,259 579,264 SH   SOLE   579,264 0 0
Compugen Ltd EQUITIES M25722105   231,792 330,188 SH   SOLE   330,188 0 0
Cue Biopharma Inc EQUITIES 22978P106   1,093,412 306,278 SH   SOLE   306,278 0 0
Cullinan Oncology Inc EQUITIES 230031106   2,711,277 265,032 SH   SOLE   265,032 0 0
Cvrx Inc EQUITIES 126638105   279,600 30,000 SH   SOLE   30,000 0 0
Eliem Therapeutics Inc EQUITIES 28658R106   1,409,270 485,955 SH   SOLE   485,955 0 0
Eloxx Pharmaceuticals Inc EQUITIES 29014R202   135,728 54,075 SH   SOLE   54,075 0 0
Fresh Tracks Therapeutics Inc EQUITIES 10802T204   6,600 10,000 SH   SOLE   10,000 0 0
Gilead Sciences Inc EQUITIES 375558103   4,988,986 60,130 SH   SOLE   60,130 0 0
Immatics Nv EQUITIES N44445109   1,948,781 282,432 SH   SOLE   282,432 0 0
ImmunoGen Inc EQUITIES 45253H101   576,000 150,000 SH   SOLE   150,000 0 0
ImmunoGen, Inc LONG OPTION CALLS 45253H101   4,332,288 1,128,200 SH Call SOLE   1,128,200 0 0
Incyte Corp EQUITIES 45337C102   2,452,699 33,938 SH   SOLE   33,938 0 0
Insmed Inc EQUITIES 457669307   2,451,688 143,794 SH   SOLE   143,794 0 0
Intellia Therapeutics Inc EQUITIES 45826J105   1,410,968 37,858 SH   SOLE   37,858 0 0
Intra-Cellular Therapies Inc EQUITIES 46116X101   6,770,645 125,035 SH   SOLE   125,035 0 0
Jasper Therapeutics Inc EQUITIES 471871103   905,000 500,000 SH   SOLE   500,000 0 0
KalVista Pharmaceuticals Inc EQUITIES 483497103   5,687,056 723,544 SH   SOLE   723,544 0 0
Karyopharm Therapeutics Inc EQUITIES 48576U106   5,996,147 1,541,426 SH   SOLE   1,541,426 0 0
Krystal Biotech Inc EQUITIES 501147102   2,723,161 34,014 SH   SOLE   34,014 0 0
LAVA Therapeutics NV EQUITIES N51517105   232,883 140,291 SH   SOLE   140,291 0 0
MacroGenics Inc EQUITIES 556099109   9,764,171 1,361,809 SH   SOLE   1,361,809 0 0
Madrigal Pharmaceuticals Inc EQUITIES 558868105   2,422,600 10,000 SH   SOLE   10,000 0 0
Mersana Therapeutics Inc EQUITIES 59045L106   2,219,642 540,059 SH   SOLE   540,059 0 0
Merus NV EQUITIES N5749R100   12,305,626 668,784 SH   SOLE   668,784 0 0
Mirum Pharmaceuticals Inc EQUITIES 604749101   2,544,655 105,939 SH   SOLE   105,939 0 0
Monte Rosa Therapeutics Inc EQUITIES 61225M102   242,705 31,156 SH   SOLE   31,156 0 0
MoonLake Immunotherapeutics EQUITIES 61559X104   2,261,993 105,750 SH   SOLE   105,750 0 0
Morphic Holding Inc EQUITIES 61775R105   1,945,386 51,684 SH   SOLE   51,684 0 0
Nuvalent Inc EQUITIES 670703107   7,345,196 281,533 SH   SOLE   281,533 0 0
Oric Pharmaceuticals Inc EQUITIES 68622P109   8,184,887 1,435,945 SH   SOLE   1,435,945 0 0
Pharvaris NV EQUITIES N69605108   4,505,862 559,387 SH   SOLE   559,387 0 0
Phathom Pharmaceuticals Inc EQUITIES 71722W107   1,428,000 200,000 SH   SOLE   200,000 0 0
Pliant Therapeutics Inc EQUITIES 729139105   2,660,000 100,000 SH   SOLE   100,000 0 0
Pliant Therapeutics, Inc LONG OPTION CALLS 729139105   5,309,360 199,600 SH Call SOLE   199,600 0 0
Point Biopharma Global Inc EQUITIES 730541109   1,442,928 198,477 SH   SOLE   198,477 0 0
Poseida Therapeutics Inc EQUITIES 73730P108   8,283,047 2,689,301 SH   SOLE   2,689,301 0 0
Prometheus Biosciences Inc EQUITIES 74349U108   1,494,002 13,921 SH   SOLE   13,921 0 0
Protagonist Therapeutics Inc EQUITIES 74366E102   2,426,178 105,486 SH   SOLE   105,486 0 0
Regeneron Pharmaceuticals Inc EQUITIES 75886F107   4,108,350 5,000 SH   SOLE   5,000 0 0
Rocket Pharmaceuticals Inc WARRANTS 77313F114   11,531 104,828 SH   SOLE   104,828 0 0
Sarepta Therapeutics Inc EQUITIES 803607100   1,277,684 9,270 SH   SOLE   9,270 0 0
Schrodinger Inc EQUITIES 80810D103   5,603,682 212,825 SH   SOLE   212,825 0 0
Seres Therapeutics Inc EQUITIES 81750R102   1,318,417 232,525 SH   SOLE   232,525 0 0
Tela Bio Inc EQUITIES 872381108   575,581 54,096 SH   SOLE   54,096 0 0
Terns Pharmaceuticals Inc EQUITIES 880881107   7,908,196 667,922 SH   SOLE   667,922 0 0
Trevi Therapeutics Inc EQUITIES 89532M101   1,638,959 885,924 SH   SOLE   885,924 0 0
United Therapeutics Corp EQUITIES 91307C102   4,160,729 18,578 SH   SOLE   18,578 0 0
Ventyx Biosciences Inc EQUITIES 92332V107   2,345,000 70,000 SH   SOLE   70,000 0 0
Veracyte Inc EQUITIES 92337F107   4,675,262 209,653 SH   SOLE   209,653 0 0
Vertex Pharmaceuticals Inc EQUITIES 92532F100   4,152,938 13,181 SH   SOLE   13,181 0 0
Viewray Inc EQUITIES 92672L107   9,666,368 2,793,748 SH   SOLE   2,793,748 0 0
Viking Therapeutics Inc EQUITIES 92686J106   6,327,000 380,000 SH   SOLE   380,000 0 0
Viridian Therapeutics Inc EQUITIES 92790C104   925,533 36,381 SH   SOLE   36,381 0 0
Xenon Pharmaceuticals Inc EQUITIES 98420N105   3,458,853 96,643 SH   SOLE   96,643 0 0