The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   51,238,092 321,504 SH   DFND 1 321,504 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109   75,161,964 1,040,304 SH   DFND 1 1,040,304 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   4,705,000 250,000 SH   DFND 1 250,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109   45,754,274 534,575 SH   DFND 1 534,575 0 0
ADDUS HOMECARE CORP COM 006739106   40,559,512 379,913 SH   DFND 1 379,913 0 0
ADVANCED MICRO DEVICES INC COM 007903107   379,534,120 3,872,402 SH   DFND 1 3,872,402 0 0
AFFILIATED MANAGERS GROUP IN COM 008252108   20,352,673 142,906 SH   DFND 1 142,906 0 0
AFLAC INC COM 001055102   33,550,400 520,000 SH   DFND 1 520,000 0 0
AGILENT TECHNOLOGIES INC COM 00846U101   20,059,300 145,000 SH   DFND 1 145,000 0 0
AIR PRODS & CHEMS INC COM 009158106   4,480,476 15,600 SH   DFND 1,2 15,600 0 0
AIR TRANS SVCS GROUP INC NOTE 1.125%10/1 00922RAB1   18,027,887 18,915,000 PRN   DFND 1 18,915,000 0 0
AIRBNB INC COM CL A 009066101   88,517,442 711,555 SH   DFND 1 711,555 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.125% 5/0 00971TAJ0   11,113,755 11,000,000 PRN   DFND 1 11,000,000 0 0
AKOYA BIOSCIENCES INC COM 00974H104   10,760,545 1,315,470 SH   DFND 1 1,315,470 0 0
ALBEMARLE CORP COM 012653101   1,492,020 6,750 SH   DFND 1,2 6,750 0 0
ALCON AG ORD SHS H01301128   23,601,767 334,587 SH   DFND 1 334,587 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   86,912,367 850,581 SH   DFND 1 850,581 0 0
ALKERMES PLC SHS G01767105   81,413,171 2,888,016 SH   DFND 1 2,888,016 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   62,483,414 311,918 SH   DFND 1 311,918 0 0
ALPHABET INC CAP STK CL A 02079K305   231,123,821 2,228,129 SH   DFND 1 2,228,129 0 0
ALPHABET INC CAP STK CL C 02079K107   256,677,720 2,468,055 SH   DFND 1 2,468,055 0 0
ALPHABET INC CAP STK CL A 02079K305   2,282,060 22,000 SH Call DFND 1 22,000 0 0
AMAZON COM INC COM 023135106   131,368,767 1,271,844 SH   DFND 1 1,271,844 0 0
AMDOCS LTD SHS G02602103   26,293,974 273,810 SH   DFND 1 273,810 0 0
AMGEN INC COM 031162100   5,655,016 23,392 SH   DFND 1 23,392 0 0
ANALOG DEVICES INC COM 032654105   87,169,268 441,990 SH   DFND 1,2 441,990 0 0
ANNEXON INC COM 03589W102   3,850,000 1,000,000 SH   DFND 1 1,000,000 0 0
AON PLC SHS CL A G0403H108   91,434,100 290,000 SH   DFND 1 290,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   30,671,400 465,000 SH   DFND 1 465,000 0 0
APPLE INC COM 037833100   663,881,299 4,025,963 SH   DFND 1 4,025,963 0 0
APTARGROUP INC COM 038336103   10,873,244 91,998 SH   DFND 1 91,998 0 0
APTIV PLC SHS G6095L109   560,950 5,000 SH   DFND 2 5,000 0 0
ARCH CAP GROUP LTD ORD G0450A105   265,508,322 3,912,013 SH   DFND 1 3,912,013 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   34,490,643 3,135,513 SH   DFND 1 3,135,513 0 0
ARES CAPITAL CORP COM 04010L103   4,635,783 253,668 SH   DFND 1 253,668 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101   6,323,584 75,786 SH   DFND 1 75,786 0 0
ARISTA NETWORKS INC COM 040413106   146,126,830 870,528 SH   DFND 1 870,528 0 0
ARRAY TECHNOLOGIES INC COM SHS 04271T100   8,248,760 377,000 SH   DFND 1,2 377,000 0 0
ARRAY TECHNOLOGIES INC NOTE 1.000%12/0 04271TAB6   12,533,447 11,350,000 PRN   DFND 1 11,350,000 0 0
ASPEN TECHNOLOGY INC COM 29109X106   2,810,981 12,282 SH   DFND 1 12,282 0 0
ATLASSIAN CORPORATION CL A 049468101   17,547,664 102,516 SH   DFND 1 102,516 0 0
ATRICURE INC COM 04963C209   638,952 15,415 SH   DFND 1 15,415 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   41,884,008 4,572,490 SH   DFND 1 4,572,490 0 0
AVANTOR INC COM 05352A100   16,929,863 800,845 SH   DFND 1 800,845 0 0
AXON ENTERPRISE INC COM 05464C101   10,599,654 47,141 SH   DFND 1 47,141 0 0
BAIDU INC SPON ADR REP A 056752108   86,963,424 576,222 SH   DFND 1 576,222 0 0
BAKER HUGHES COMPANY CL A 05722G100   9,715,950 336,658 SH   DFND 1 336,658 0 0
BANK AMERICA CORP COM 060505104   16,713,211 584,378 SH   DFND 1 584,378 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   25,612,020 3,557,225 SH   DFND 1 3,557,225 0 0
BENTLEY SYS INC NOTE 0.375% 7/0 08265TAD1   6,367,500 7,500,000 PRN   DFND 1 7,500,000 0 0
BERKLEY W R CORP COM 084423102   114,402,750 1,837,500 SH   DFND 1 1,837,500 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702   61,471,167 199,084 SH   DFND 1 199,084 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   21,472,065 1,009,500 SH   DFND 1 1,009,500 0 0
BIO RAD LABS INC CL A 090572207   70,850,411 147,907 SH   DFND 1 147,907 0 0
BIOGEN INC COM 09062X103   69,507,500 250,000 SH   DFND 1 250,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   41,327,000 425,000 SH   DFND 1 425,000 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4   17,689,839 17,200,000 PRN   DFND 1 17,200,000 0 0
BIOMEA FUSION INC COM 09077A106   18,140,850 585,000 SH   DFND 1 585,000 0 0
BLACKLINE INC NOTE 3/1 09239BAD1   34,739,375 40,750,000 PRN   DFND 1 40,750,000 0 0
BLOCK INC NOTE 0.500% 5/1 852234AD5   3,607,729 3,500,000 PRN   DFND 1 3,500,000 0 0
BOOKING HOLDINGS INC COM 09857L108   23,505,657 8,862 SH   DFND 1 8,862 0 0
BOSTON SCIENTIFIC CORP COM 101137107   62,734,668 1,253,941 SH   DFND 1 1,253,941 0 0
BRAZE INC COM CL A 10576N102   5,428,320 157,024 SH   DFND 1 157,024 0 0
BRUKER CORP COM 116794108   471,069 5,975 SH   DFND 1 5,975 0 0
CANADIAN NAT RES LTD COM 136385101   24,130,718 435,966 SH   DFND 1 435,966 0 0
CANNAE HLDGS INC COM 13765N107   15,304,411 758,395 SH   DFND 1 758,395 0 0
CASTLE BIOSCIENCES INC COM 14843C105   304,403 13,398 SH   DFND 1 13,398 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   81,602,244 2,267,989 SH   DFND 1 2,267,989 0 0
CENOVUS ENERGY INC COM 15135U109   21,924,679 1,255,709 SH   DFND 1 1,255,709 0 0
CENTENE CORP DEL COM 15135B101   16,883,201 267,097 SH   DFND 1 267,097 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   18,738,252 768,276 SH   DFND 1 768,276 0 0
CERIDIAN HCM HLDG INC NOTE 0.250% 3/1 15677JAD0   14,250,283 15,800,000 PRN   DFND 1 15,800,000 0 0
CERUS CORP COM 157085101   6,944,282 2,338,142 SH   DFND 1 2,338,142 0 0
CHEGG INC NOTE 9/0 163092AF6   15,899,808 20,000,000 PRN   DFND 1 20,000,000 0 0
CHEMED CORP NEW COM 16359R103   5,646,375 10,500 SH   DFND 1 10,500 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   4,051,250 175,000 SH   DFND 1 175,000 0 0
CHUBB LIMITED COM H1467J104   186,141,919 958,605 SH   DFND 1 958,605 0 0
CITIZENS FINL GROUP INC COM 174610105   5,173,135 170,337 SH   DFND 1 170,337 0 0
CLOUDFLARE INC CL A COM 18915M107   110,376,086 1,790,076 SH   DFND 1 1,790,076 0 0
COGNEX CORP COM 192422103   12,663,642 255,573 SH   DFND 1,2 255,573 0 0
CONFLUENT INC CLASS A COM 20717M103   64,943,315 2,698,102 SH   DFND 1 2,698,102 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105   132,655,613 966,455 SH   DFND 1 966,455 0 0
CYBERARK SOFTWARE LTD SHS M2682V108   113,236,072 765,212 SH   DFND 1 765,212 0 0
CYTOKINETICS INC COM NEW 23282W605   91,905,441 2,611,692 SH   DFND 1 2,611,692 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   18,711,957 1,399,548 SH   DFND 1 1,399,548 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101   27,037,500 1,750,000 SH   DFND 1 1,750,000 0 0
DENALI THERAPEUTICS INC COM 24823R105   11,635,200 505,000 SH   DFND 1 505,000 0 0
DEXCOM INC COM 252131107   99,804,080 859,047 SH   DFND 1 859,047 0 0
DEXCOM INC NOTE 0.250%11/1 252131AK3   1,614,236 1,500,000 PRN   DFND 1 1,500,000 0 0
DROPBOX INC NOTE 3/0 26210CAD6   8,734,061 10,000,000 PRN   DFND 1 10,000,000 0 0
DYNATRACE INC COM NEW 268150109   28,569,547 675,403 SH   DFND 1 675,403 0 0
ELASTIC N V ORD SHS N14506104   16,650,303 287,570 SH   DFND 1 287,570 0 0
ELEVANCE HEALTH INC COM 036752103   13,024,578 28,326 SH   DFND 1 28,326 0 0
EMERSON ELEC CO COM 291011104   4,533,633 52,027 SH   DFND 1 52,027 0 0
ENCORE CAP EUROPE FIN LTD NOTE 4.500% 9/0 29260UAA5   2,661,500 2,250,000 PRN   DFND 1 2,250,000 0 0
ENERSYS COM 29275Y102   2,893,104 33,300 SH   DFND 1,2 33,300 0 0
ENPHASE ENERGY INC COM 29355A107   41,253,572 196,184 SH   DFND 1,2 196,184 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104   9,700,006 237,280 SH   DFND 1 237,280 0 0
ESSENT GROUP LTD COM G3198U102   118,147,500 2,950,000 SH   DFND 1 2,950,000 0 0
EVEREST RE GROUP LTD COM G3223R108   100,245,600 280,000 SH   DFND 1 280,000 0 0
EVOLENT HEALTH INC CL A 30050B101   1,514,539 46,673 SH   DFND 1 46,673 0 0
EXACT SCIENCES CORP COM 30063P105   516,034 7,610 SH   DFND 1 7,610 0 0
EXELIXIS INC COM 30161Q104   64,458,630 3,320,898 SH   DFND 1 3,320,898 0 0
FARFETCH LTD ORD SH CL A 30744W107   567,365 115,553 SH   DFND 1 115,553 0 0
FERGUSON PLC NEW SHS G3421J106   211,012,672 161,195 SH   DFND 1 161,195 0 0
FIRST AMERN FINL CORP COM 31847R102   52,877,000 950,000 SH   DFND 1 950,000 0 0
FIRST SOLAR INC COM 336433107   71,842,643 330,311 SH   DFND 1,2 330,311 0 0
FISERV INC COM 337738108   18,120,404 160,315 SH   DFND 1 160,315 0 0
FLYWIRE CORPORATION COM VTG 302492103   12,368,223 421,261 SH   DFND 1 421,261 0 0
FORD MTR CO DEL NOTE 3/1 345370CZ1   7,530,000 7,500,000 PRN   DFND 1 7,500,000 0 0
FRESHWORKS INC CLASS A COM 358054104   37,229,583 2,423,801 SH   DFND 1 2,423,801 0 0
GITLAB INC CLASS A COM 37637K108   31,516,213 919,108 SH   DFND 1 919,108 0 0
GLOBANT S A COM L44385109   21,727,225 132,475 SH   DFND 1 132,475 0 0
GOLUB CAP BDC INC COM 38173M102   3,843,379 283,435 SH   DFND 1 283,435 0 0
GUARDANT HEALTH INC NOTE 11/1 40131MAB5   12,831,263 19,000,000 PRN   DFND 1 19,000,000 0 0
H WORLD GROUP LTD SPONSORED ADS 44332N106   2,727,010 55,676 SH   DFND 1 55,676 0 0
H WORLD GROUP LTD NOTE 3.000% 5/0 44332NAB2   6,757,500 5,000,000 PRN   DFND 1 5,000,000 0 0
HAGERTY INC CL A COM 405166109   40,044,102 4,581,705 SH   DFND 1 4,581,705 0 0
HASHICORP INC COM CL A 418100103   4,222,359 144,157 SH   DFND 1 144,157 0 0
HCA HEALTHCARE INC COM 40412C101   61,606,723 233,642 SH   DFND 1 233,642 0 0
HOLOGIC INC COM 436440101   5,690,722 70,517 SH   DFND 1 70,517 0 0
HUBSPOT INC COM 443573100   183,122,126 427,107 SH   DFND 1 427,107 0 0
HUMANA INC COM 444859102   22,567,094 46,486 SH   DFND 1 46,486 0 0
ICON PLC SHS G4705A100   18,657,087 87,350 SH   DFND 1 87,350 0 0
IMPINJ INC COM 453204109   9,568,254 70,604 SH   DFND 1 70,604 0 0
INARI MED INC COM 45332Y109   526,334 8,525 SH   DFND 1 8,525 0 0
INCYTE CORP COM 45337C102   79,497,000 1,100,000 SH   DFND 1 1,100,000 0 0
INSMED INC COM PAR $.01 457669307   28,837,500 1,691,349 SH   DFND 1 1,691,349 0 0
INSPIRE MED SYS INC COM 457730109   62,882,906 268,650 SH   DFND 1 268,650 0 0
INSULET CORP COM 45784P101   5,096,662 15,979 SH   DFND 1 15,979 0 0
INSULET CORP NOTE 0.375% 9/0 45784PAK7   5,244,750 3,500,000 PRN   DFND 1 3,500,000 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104   20,959,161 200,970 SH   DFND 1 200,970 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   21,660,000 400,000 SH   DFND 1 400,000 0 0
INTUIT COM 461202103   13,301,784 29,836 SH   DFND 1 29,836 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   97,442,134 381,423 SH   DFND 1 381,423 0 0
IQVIA HLDGS INC COM 46266C105   17,340,225 87,185 SH   DFND 1 87,185 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106   793,792 6,400 SH   DFND 1 6,400 0 0
IVERIC BIO INC COM 46583P102   33,137,484 1,362,001 SH   DFND 1 1,362,001 0 0
JAMES RIV GROUP LTD COM G5005R107   25,038,125 1,212,500 SH   DFND 1 1,212,500 0 0
JD.COM INC SPON ADR CL A 47215P106   414,102 9,435 SH   DFND 1 9,435 0 0
JETBLUE AIRWAYS CORP NOTE 0.500% 4/0 477143AP6   7,720,000 10,000,000 PRN   DFND 1 10,000,000 0 0
JOHNSON & JOHNSON COM 478160104   62,599,075 403,865 SH   DFND 1 403,865 0 0
JPMORGAN CHASE & CO COM 46625H100   41,375,249 317,514 SH   DFND 1 317,514 0 0
KE HLDGS INC SPONSORED ADS 482497104   312,782 16,602 SH   DFND 1 16,602 0 0
KLA CORP COM NEW 482480100   156,215,978 391,352 SH   DFND 1 391,352 0 0
LANTHEUS HLDGS INC COM 516544103   1,226,429 14,855 SH   DFND 1 14,855 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104   160,263,421 1,678,151 SH   DFND 1,2 1,678,151 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   95,264,927 1,975,631 SH   DFND 1 1,975,631 0 0
LI AUTO INC NOTE 0.250% 5/0 50202MAB8   557,000 500,000 PRN   DFND 1 500,000 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854   13,191,930 176,292 SH   DFND 1 176,292 0 0
LILLY ELI & CO COM 532457108   47,643,687 138,733 SH   DFND 1 138,733 0 0
LINDE PLC SHS G54950103   27,823,488 78,279 SH   DFND 1,2 78,279 0 0
LITTELFUSE INC COM 537008104   9,977,237 37,216 SH   DFND 1 37,216 0 0
LIVANOVA PLC SHS G5509L101   28,606,609 656,416 SH   DFND 1 656,416 0 0
LIVENT CORP COM 53814L108   3,414,384 157,200 SH   DFND 1,2 157,200 0 0
LYFT INC NOTE 1.500% 5/1 55087PAB0   13,906,161 15,750,000 PRN   DFND 1 15,750,000 0 0
MACOM TECH SOLUTIONS HLDGS I NOTE 0.250% 3/1 55405YAB6   4,226,000 4,000,000 PRN   DFND 1 4,000,000 0 0
MARKEL CORP COM 570535104   145,305,388 113,750 SH   DFND 1 113,750 0 0
MARRIOTT VACATIONS WORLDWIDE NOTE 1/1 57164YAD9   3,405,500 3,500,000 PRN   DFND 1 3,500,000 0 0
MARSH & MCLENNAN COS INC COM 571748102   181,354,130 1,088,887 SH   DFND 1 1,088,887 0 0
MARVELL TECHNOLOGY INC COM 573874104   65,738,926 1,518,220 SH   DFND 1,2 1,518,220 0 0
MASTERCARD INCORPORATED CL A 57636Q104   104,869,951 288,572 SH   DFND 1 288,572 0 0
MAXEON SOLAR TECHNOLOGIES LT SHS Y58473102   2,441,680 92,000 SH   DFND 1,2 92,000 0 0
MERCADOLIBRE INC COM 58733R102   161,161,832 122,272 SH   DFND 1 122,272 0 0
MERIT MED SYS INC COM 589889104   36,156,300 488,929 SH   DFND 1 488,929 0 0
MERUS N V COM N5749R100   13,800,000 750,000 SH   DFND 1 750,000 0 0
META PLATFORMS INC CL A 30303M102   203,381,015 959,616 SH   DFND 1 959,616 0 0
MICRON TECHNOLOGY INC COM 595112103   6,550,390 108,558 SH   DFND 1 108,558 0 0
MICROSOFT CORP COM 594918104   793,869,799 2,753,624 SH   DFND 1 2,753,624 0 0
MICROSOFT CORP COM 594918104   3,834,390 13,300 SH Call DFND 1 13,300 0 0
MIDDLEBY CORP NOTE 1.000% 9/0 596278AB7   2,179,213 1,750,000 PRN   DFND 1 1,750,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   22,336,366 929,907 SH   DFND 1 929,907 0 0
MKS INSTRS INC COM 55306N104   9,849,050 111,138 SH   DFND 1 111,138 0 0
MOBILEYE GLOBAL INC COMMON CLASS A 60741F104   5,131,476 118,592 SH   DFND 1 118,592 0 0
MOLINA HEALTHCARE INC COM 60855R100   6,860,049 25,646 SH   DFND 1 25,646 0 0
MONGODB INC CL A 60937P106   38,805,388 166,461 SH   DFND 1 166,461 0 0
MONOLITHIC PWR SYS INC COM 609839105   168,668,465 336,973 SH   DFND 1,2 336,973 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   18,745,704 876,377 SH   DFND 1 876,377 0 0
MORGAN STANLEY COM NEW 617446448   9,609,973 109,453 SH   DFND 1 109,453 0 0
MP MATERIALS CORP COM CL A 553368101   9,429,555 334,500 SH   DFND 1,2 334,500 0 0
MSCI INC COM 55354G100   16,009,373 28,604 SH   DFND 1 28,604 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109   39,600,000 4,000,000 SH   DFND 1 4,000,000 0 0
NATERA INC COM 632307104   588,512 10,600 SH   DFND 1 10,600 0 0
NCL CORP LTD NOTE 5.375% 8/0 62886HAX9   5,407,500 5,000,000 PRN   DFND 1 5,000,000 0 0
NETEASE INC SPONSORED ADS 64110W102   333,773 3,774 SH   DFND 1 3,774 0 0
NIO INC SPON ADS 62914V106   7,062,720 672,000 SH   DFND 1,2 672,000 0 0
NORFOLK SOUTHN CORP COM 655844108   12,763,672 60,206 SH   DFND 1 60,206 0 0
NUTANIX INC NOTE 0.250%10/0 67059NAH1   30,189,409 36,010,000 PRN   DFND 1 36,010,000 0 0
NVIDIA CORPORATION COM 67066G104   404,966,994 1,457,922 SH   DFND 1 1,457,922 0 0
NXP SEMICONDUCTORS N V COM N6596X109   540,778 2,900 SH   DFND 2 2,900 0 0
OMNICELL COM COM 68213N109   209,335 3,568 SH   DFND 1 3,568 0 0
ON SEMICONDUCTOR CORP COM 682189105   121,341,326 1,474,020 SH   DFND 1,2 1,474,020 0 0
OPTION CARE HEALTH INC COM NEW 68404L201   61,229,559 1,927,276 SH   DFND 1 1,927,276 0 0
OVINTIV INC COM 69047Q102   10,224,639 283,388 SH   DFND 1 283,388 0 0
PACIRA BIOSCIENCES INC COM 695127100   514,002 12,595 SH   DFND 1 12,595 0 0
PALO ALTO NETWORKS INC COM 697435105   140,254,232 702,184 SH   DFND 1 702,184 0 0
PATRICK INDS INC NOTE 1.750%12/0 703343AG8   2,724,000 3,000,000 PRN   DFND 1 3,000,000 0 0
PAYCOM SOFTWARE INC COM 70432V102   16,532,368 54,381 SH   DFND 1 54,381 0 0
PENUMBRA INC COM 70975L107   36,059,142 129,388 SH   DFND 1 129,388 0 0
PINTEREST INC CL A 72352L106   52,359,136 1,920,027 SH   DFND 1 1,920,027 0 0
PLIANT THERAPEUTICS INC COM 729139105   47,432,162 1,783,164 SH   DFND 1 1,783,164 0 0
PLUG POWER INC COM NEW 72919P202   990,340 84,500 SH   DFND 1,2 84,500 0 0
PNC FINL SVCS GROUP INC COM 693475105   9,455,223 74,392 SH   DFND 1 74,392 0 0
POWER INTEGRATIONS INC COM 739276103   34,885,476 412,163 SH   DFND 1,2 412,163 0 0
PRIVIA HEALTH GROUP INC COM 74276R102   711,372 25,765 SH   DFND 1 25,765 0 0
PROASSURANCE CORP COM 74267C106   39,963,000 2,162,500 SH   DFND 1 2,162,500 0 0
PROGRESSIVE CORP COM 743315103   85,836,000 600,000 SH   DFND 1 600,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   9,927,100 92,500 SH   DFND 1 92,500 0 0
PURE STORAGE INC CL A 74624M102   39,702,284 1,556,342 SH   DFND 1 1,556,342 0 0
PURE STORAGE INC NOTE 0.125% 4/1 74624MAB8   3,056,551 3,000,000 PRN   DFND 1 3,000,000 0 0
QIAGEN NV SHS NEW N72482123   20,219,213 440,218 SH   DFND 1 440,218 0 0
QORVO INC COM 74736K101   3,229,926 31,800 SH   DFND 1,2 31,800 0 0
QUALCOMM INC COM 747525103   136,273,301 1,068,140 SH   DFND 1 1,068,140 0 0
QUIDELORTHO CORP COM 219798105   924,309 10,375 SH   DFND 1 10,375 0 0
R1 RCM INC COM 77634L105   10,791,120 719,408 SH   DFND 1 719,408 0 0
REGENERON PHARMACEUTICALS COM 75886F107   108,871,275 132,500 SH   DFND 1 132,500 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604   75,673,200 570,000 SH   DFND 1 570,000 0 0
RENAISSANCERE HLDGS LTD COM G7496G103   204,764,709 1,022,086 SH   DFND 1 1,022,086 0 0
REVANCE THERAPEUTICS INC COM 761330109   134,246,191 4,167,842 SH   DFND 1 4,167,842 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   31,220,000 1,750,000 SH   DFND 1 1,750,000 0 0
RLI CORP COM 749607107   34,556,600 260,000 SH   DFND 1 260,000 0 0
ROBLOX CORP CL A 771049103   73,647,148 1,637,331 SH   DFND 1 1,637,331 0 0
ROCKWELL AUTOMATION INC COM 773903109   7,511,733 25,598 SH   DFND 1 25,598 0 0
ROYAL BK CDA SUSTAINABL COM 780087102   6,775,188 70,885 SH   DFND 1 70,885 0 0
RYAN SPECIALTY HOLDINGS INC CL A 78351F107   53,318,000 1,325,000 SH   DFND 1 1,325,000 0 0
S&P GLOBAL INC COM 78409V104   6,353,422 18,428 SH   DFND 1 18,428 0 0
SABRE CORP COM 78573M104   3,609,061 841,273 SH   DFND 1 841,273 0 0
SALESFORCE INC COM 79466L302   77,636,306 388,609 SH   DFND 1 388,609 0 0
SANOFI SPONSORED ADR 80105N105   54,420,000 1,000,000 SH   DFND 1 1,000,000 0 0
SCHWAB CHARLES CORP COM 808513105   3,200,523 61,102 SH   DFND 1 61,102 0 0
SEA LTD SPONSORD ADS 81141R100   42,504,445 491,097 SH   DFND 1 491,097 0 0
SEA LTD NOTE 2.375%12/0 81141RAF7   12,488,856 10,200,000 PRN   DFND 1 10,200,000 0 0
SEA LTD NOTE 0.250% 9/1 81141RAG5   2,365,500 3,000,000 PRN   DFND 1 3,000,000 0 0
SEAGEN INC COM 81181C104   111,235,398 549,392 SH   DFND 1 549,392 0 0
SERVICE CORP INTL COM 817565104   12,545,128 182,395 SH   DFND 1 182,395 0 0
SERVICENOW INC COM 81762P102   186,867,630 402,108 SH   DFND 1 402,108 0 0
SHIFT4 PMTS INC NOTE 12/1 82452JAB5   9,682,207 8,250,000 PRN   DFND 1 8,250,000 0 0
SHOALS TECHNOLOGIES GROUP IN CL A 82489W107   9,366,690 411,000 SH   DFND 1,2 411,000 0 0
SHOPIFY INC CL A 82509L107   102,242,597 2,132,720 SH   DFND 1 2,132,720 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4   4,707,758 3,141,000 PRN   DFND 1 3,141,000 0 0
SITIME CORP COM 82982T106   56,789,737 399,281 SH   DFND 1 399,281 0 0
SMARTSHEET INC COM CL A 83200N103   49,333,854 1,032,089 SH   DFND 1 1,032,089 0 0
SNAP INC NOTE 0.750% 8/0 83304AAB2   1,747,525 1,900,000 PRN   DFND 1 1,900,000 0 0
SNOWFLAKE INC CL A 833445109   48,448,294 314,008 SH   DFND 1 314,008 0 0
SOLAREDGE TECHNOLOGIES INC NOTE 9/1 83417MAD6   9,107,000 7,000,000 PRN   DFND 1 7,000,000 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   55,491,544 182,568 SH   DFND 1,2 182,568 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2   3,989,125 3,500,000 PRN   DFND 1 3,500,000 0 0
SPLUNK INC NOTE 1.125% 9/1 848637AD6   6,305,829 6,500,000 PRN   DFND 1 6,500,000 0 0
SS&C TECHNOLOGIES HLDGS INC COM 78467J100   20,308,363 359,631 SH   DFND 1 359,631 0 0
SSR MINING IN NOTE 2.500% 4/0 784730AB9   20,722,900 18,839,000 PRN   DFND 1 18,839,000 0 0
STANDARD BIOTOOLS INC COM 34385P108   195,000 100,000 SH   DFND 1 100,000 0 0
STEREOTAXIS INC COM NEW 85916J409   156,441 76,687 SH   DFND 1 76,687 0 0
STRYKER CORPORATION COM 863667101   9,003,438 31,539 SH   DFND 1 31,539 0 0
SUNPOWER CORP COM 867652406   1,273,280 92,000 SH   DFND 1,2 92,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108   50,266,045 1,387,415 SH   DFND 1 1,387,415 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   455,238 11,210 SH   DFND 1 11,210 0 0
TE CONNECTIVITY LTD SHS H84989104   9,267,846 70,666 SH   DFND 1,2 70,666 0 0
TECK RESOURCES LTD CL B 878742204   13,224,899 362,326 SH   DFND 1 362,326 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   13,082,799 220,175 SH   DFND 1 220,175 0 0
TERADYNE INC COM 880770102   90,685,653 843,509 SH   DFND 1 843,509 0 0
TESLA INC COM 88160R101   50,349,090 242,693 SH   DFND 1 242,693 0 0
THE TRADE DESK INC COM CL A 88339J105   7,199,562 118,200 SH   DFND 1 118,200 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   7,964,857 13,819 SH   DFND 1 13,819 0 0
T-MOBILE US INC COM 872590104   26,668,230 184,122 SH   DFND 1 184,122 0 0
TORONTO DOMINION BK ONT COM NEW 891160509   13,438,206 224,344 SH   DFND 1 224,344 0 0
TRAVELERS COMPANIES INC COM 89417E109   105,225,856 613,884 SH   DFND 1 613,884 0 0
TRIMBLE INC COM 896239100   288,310 5,500 SH   DFND 2 5,500 0 0
TRIP COM GROUP LTD ADS 89677Q107   88,482,686 2,348,890 SH   DFND 1 2,348,890 0 0
TRIPADVISOR INC COM 896945201   55,806,084 2,809,974 SH   DFND 1 2,809,974 0 0
TRUPANION INC COM 898202106   47,179,000 1,100,000 SH   DFND 1 1,100,000 0 0
UBER TECHNOLOGIES INC COM 90353T100   107,967,949 3,405,929 SH   DFND 1,2 3,405,929 0 0
UBS GROUP AG SHS H42097107   533,500 25,000 SH   DFND 1 25,000 0 0
UNION PAC CORP COM 907818108   17,198,271 85,453 SH   DFND 1 85,453 0 0
UNITED RENTALS INC COM 911363109   28,845,363 72,886 SH   DFND 1 72,886 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   72,579,837 324,075 SH   DFND 1 324,075 0 0
UNITEDHEALTH GROUP INC COM 91324P102   9,195,184 19,457 SH   DFND 1 19,457 0 0
US BANCORP DEL COM NEW 902973304   6,239,570 173,081 SH   DFND 1 173,081 0 0
US FOODS HLDG CORP COM 912008109   28,944,743 783,561 SH   DFND 1 783,561 0 0
VEEVA SYS INC CL A COM 922475108   15,055,893 81,919 SH   DFND 1 81,919 0 0
VERADIGM INC COM 01988P108   363,508 27,855 SH   DFND 1 27,855 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   118,151,250 375,000 SH   DFND 1 375,000 0 0
VERTIV HOLDINGS CO COM CL A 92537N108   10,174,410 711,000 SH   DFND 1,2 711,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   13,992,000 550,000 SH   DFND 1 550,000 0 0
VISA INC COM CL A 92826C839   161,376,828 715,767 SH   DFND 1 715,767 0 0
VISTEON CORP COM NEW 92839U206   439,124 2,800 SH   DFND 2 2,800 0 0
WALMART INC COM 931142103   7,732,868 52,444 SH   DFND 1 52,444 0 0
WELLS FARGO CO NEW COM 949746101   20,325,263 543,747 SH   DFND 1 543,747 0 0
WINNEBAGO INDS INC NOTE 1.500% 4/0 974637AB6   4,970,250 4,500,000 PRN   DFND 1 4,500,000 0 0
WORKDAY INC CL A 98138H101   125,794,013 609,054 SH   DFND 1 609,054 0 0
Y-MABS THERAPEUTICS INC COM 984241109   9,979,564 1,991,929 SH   DFND 1 1,991,929 0 0
ZAI LAB LTD ADR 98887Q104   5,640,098 169,576 SH   DFND 1 169,576 0 0
ZILLOW GROUP INC NOTE 1.375% 9/0 98954MAG6   7,712,250 6,500,000 PRN   DFND 1 6,500,000 0 0