The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106   94,408 12,521 SH   DFND 1,2 12,521 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   564,299 29,984 SH   DFND 1,2 29,984 0 0
AEROVATE THERAPEUTICS INC COM 008064107   966,869 47,936 SH   DFND 1,2 47,936 0 0
AFFIMED N V COM N01045108   277,715 372,472 SH   DFND 1,2 372,472 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   189,614 41,950 SH   DFND 1,2 41,950 0 0
ARGENX SE SPONSORED ADR 04016X101   532,789 1,430 SH   DFND 1,2 1,430 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101   446,893 4,168 SH   DFND 1,2 4,168 0 0
BEIGENE LTD SPONSORED ADR 07725L102   2,591,102 12,022 SH   DFND 1,2 12,022 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   148,844 17,847 SH   DFND 1,2 17,847 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   701,587 7,215 SH   DFND 1,2 7,215 0 0
BIOMEA FUSION INC COM 09077A106   1,860,600 60,000 SH   DFND 1,2 60,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   1,622,063 1,166,952 SH   DFND 1,2 1,166,952 0 0
CERUS CORP COM 157085101   42,091 14,172 SH   DFND 1,2 14,172 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   2,637,943 113,950 SH   DFND 1,2 113,950 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101   626,906 370,950 SH   DFND 1,2 370,950 0 0
EARGO INC COM NEW 270087208   692,191 147,904 SH   DFND 1,2 147,904 0 0
ENTRADA THERAPEUTICS INC COM 29384C108   1,066,939 73,582 SH   DFND 1,2 73,582 0 0
EXELIXIS INC COM 30161Q104   1,246,122 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102   4,557,428 859,892 SH   DFND 1,2 859,892 0 0
FIBROGEN INC COM 31572Q808   636,418 34,106 SH   DFND 1,2 34,106 0 0
GALERA THERAPEUTICS INC COM 36338D108   1,569,851 613,223 SH   DFND 1,2 613,223 0 0
GITLAB INC CLASS A COM 37637K108   1,267,084 36,952 SH   DFND 1,2 36,952 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   12,036,912 368,665 SH   DFND 1,2 368,665 0 0
ILLUMINA INC COM 452327109   27,719,030 119,196 SH   DFND 1,2 119,196 0 0
INCYTE CORP COM 45337C102   2,485,438 34,391 SH   DFND 1,2 34,391 0 0
INVITAE CORP COM 46185L103   15,305 11,337 SH   DFND 1,2 11,337 0 0
IVERIC BIO INC COM 46583P102   2,724,571 111,984 SH   DFND 1,2 111,984 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   618,739 78,720 SH   DFND 1,2 78,720 0 0
KARUNA THERAPEUTICS INC COM 48576A100   40,993,968 225,688 SH   DFND 1,2 225,688 0 0
KODIAK SCIENCES INC COM 50015M109   121,656 19,622 SH   DFND 1,2 19,622 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   286,351 1,182 SH   DFND 1,2 1,182 0 0
MERCADOLIBRE INC COM 58733R102   1,191,526 904 SH   DFND 1,2 904 0 0
MERUS N V COM N5749R100   2,778,400 151,000 SH   DFND 1,2 151,000 0 0
NURIX THERAPEUTICS INC COM 67080M103   102,120 11,500 SH   DFND 1,2 11,500 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   4,837,673 651,100 SH   DFND 1,2 651,100 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   1,582,465 136,655 SH   DFND 1,2 136,655 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100   2,546,893 493,584 SH   DFND 1,2 493,584 0 0
REPLIMUNE GROUP INC COM 76029N106   3,343,727 189,339 SH   DFND 1,2 189,339 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   580,157 32,520 SH   DFND 1,2 32,520 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107   124,263 177,900 SH   DFND 1,2 177,900 0 0
SEAGEN INC COM 81181C104   9,535,527 47,096 SH   DFND 1,2 47,096 0 0
SOMALOGIC INC CLASS A COM 83444K105   4,326,223 1,696,558 SH   DFND 1,2 1,696,558 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   575,879 25,606 SH   DFND 1,2 25,606 0 0
XENON PHARMACEUTICALS INC COM 98420N105   4,093,660 114,380 SH   DFND 1,2 114,380 0 0