The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
23ANDME HOLDING CO CLASS A COM 90138Q108   1,507 661,009 SH   DFND 1,2,3,4,5,6 661,009 0 0
2SEVENTY BIO INC COMMON STOCK 901384107   7,650 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
89BIO INC COM 282559103   7,615 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
ACHILLES THERAPEUTICS PLC SPONSORED ADS 00449L102   2,160 2,255,375 SH   DFND 1,2,3,4,5,6 2,255,375 0 0
ADAGENE INC ADS 005329107   1,450 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AGENUS INC COM NEW 00847G705   23,759 15,631,235 SH   DFND 1,2,3,4,5,6 15,631,235 0 0
ALLOVIR INC COM 019818103   21,974 5,577,167 SH   DFND 1,2,3,4,5,6 5,577,167 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100   9,210 1,193,030 SH   DFND 1,2,3,4,5,6 1,193,030 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   2,260 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
AMBRX BIOPHARMA INC SPONSORED ADS 02290A102   6,264 702,291 SH   DFND 1,2,3,4,5,6 702,291 0 0
AMERICAN INTL GROUP INC COM NEW 026874784   201 4,000 SH   DFND 1,2,3,4,5,6 4,000 0 0
AMICUS THERAPEUTICS INC COM 03152W109   39,108 3,526,407 SH   DFND 1,2,3,4,5,6 3,526,407 0 0
ANNEXON INC COM 03589W102   3,920 1,018,303 SH   DFND 1,2,3,4,5,6 1,018,303 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   80,228 1,216,312 SH   DFND 1,2,3,4,5,6 1,216,312 0 0
ARAVIVE INC COM 03890D108   9,145 4,572,515 SH   DFND 1,2,3,4,5,6 4,572,515 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   665 26,173 SH   DFND 1,2,3,4,5,6 26,173 0 0
ARVINAS INC COM 04335A105   495 18,108 SH   DFND 1,2,3,4,5,6 18,108 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   10,960 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   7,859 511,962 SH   DFND 1,2,3,4,5,6 511,962 0 0
BANK AMERICA CORP COM 060505104   229 8,000 SH   DFND 1,2,3,4,5,6 8,000 0 0
BEAM THERAPEUTICS INC COM 07373V105   336 10,975 SH   DFND 1,2,3,4,5,6 10,975 0 0
BEIGENE LTD SPONSORED ADR 07725L102   108,053 501,335 SH   DFND 1,2,3,4,5,6 501,335 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   566 67,909 SH   DFND 1,2,3,4,5,6 67,909 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   3,108 31,967 SH   DFND 1,2,3,4,5,6 31,967 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   3,112 1,646,517 SH   DFND 1,2,3,4,5,6 1,646,517 0 0
BRIDGEBIO PHARMA INC COM 10806X102   8,290 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CARIBOU BIOSCIENCES INC COM 142038108   559 105,347 SH   DFND 1,2,3,4,5,6 105,347 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   46,694 1,914,466 SH   DFND 1,2,3,4,5,6 1,914,466 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   5,989 258,687 SH   DFND 1,2,3,4,5,6 258,687 0 0
CITIZENS FINL GROUP INC COM 174610105   152 5,000 SH   DFND 1,2,3,4,5,6 5,000 0 0
CONTRAFECT CORP COM NEW 212326409   34 18,750 SH   DFND 1,2,3,4,5,6 18,750 0 0
CORVUS PHARMACEUTICALS INC COM 221015100   455 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
CULLINAN ONCOLOGY INC COM 230031106   2,558 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
CURIS INC COM NEW 231269200   775 1,300,000 SH   DFND 1,2,3,4,5,6 1,300,000 0 0
CYCLERION THERAPEUTICS INC COM 23255M105   1,201 2,768,069 SH   DFND 1,2,3,4,5,6 2,768,069 0 0
CYCLERION THERAPEUTICS INC COM 23255M105   5 11,053 SH   DFND 1,2,3,4 11,053 0 0
CYTOKINETICS INC COM NEW 23282W605   48,106 1,367,023 SH   DFND 1,2,3,4,5,6 1,367,023 0 0
DENALI THERAPEUTICS INC COM 24823R105   18,499 802,899 SH   DFND 1,2,3,4,5,6 802,899 0 0
DICE THERAPEUTICS INC COM 23345J104   124 4,318 SH   DFND 1,2,3,4,5,6 4,318 0 0
DYNE THERAPEUTICS INC COM 26818M108   6,136 532,609 SH   DFND 1,2,3,4,5,6 532,609 0 0
ERASCA INC COM 29479A108   14,211 4,721,194 SH   DFND 1,2,3,4,5,6 4,721,194 0 0
FATE THERAPEUTICS INC COM 31189P102   14,820 2,600,000 SH   DFND 1,2,3,4,5,6 2,600,000 0 0
FOGHORN THERAPEUTICS INC COM 344174107   10,668 1,720,720 SH   DFND 1,2,3,4,5,6 1,720,720 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   7,446 1,975,000 SH   DFND 1,2,3,4,5,6 1,975,000 0 0
GENERATION BIO CO COM 37148K100   12,101 2,814,191 SH   DFND 1,2,3,4,5,6 2,814,191 0 0
GERON CORP COM 374163103   12,078 5,565,889 SH   DFND 1,2,3,4,5,6 5,565,889 0 0
GLYCOMIMETICS INC COM 38000Q102   10,822 8,589,064 SH   DFND 1,2,3,4,5,6 8,589,064 0 0
GOSSAMER BIO INC COM 38341P102   3,815 3,028,171 SH   DFND 1,2,3,4,5,6 3,028,171 0 0
HARPOON THERAPEUTICS INC COM 41358P106   744 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
HIPPO HLDGS INC COM NEW 433539202   390 24,000 SH   DFND 1,2,3,4,5,6 24,000 0 0
HOOKIPA PHARMA INC COM 43906K100   1,361 1,849,616 SH   DFND 1,2,3,4,5,6 1,849,616 0 0
IGM BIOSCIENCES INC COM 449585108   34,487 2,509,972 SH   DFND 1,2,3,4,5,6 2,509,972 0 0
IKENA ONCOLOGY INC COM 45175G108   5,346 1,549,513 SH   DFND 1,2,3,4,5,6 1,549,513 0 0
I MAB SPONSORED ADS 44975P103   2,941 850,000 SH   DFND 1,2,3,4,5,6 850,000 0 0
IMMUNIC INC COM 4525EP101   1,899 1,274,713 SH   DFND 1,2,3,4,5,6 1,274,713 0 0
INTELLIA THERAPEUTICS INC COM 45826J105   10,289 276,077 SH   DFND 1,2,3,4,5,6 276,077 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108   1,163 110,532 SH   DFND 1,2,3,4 110,532 0 0
ITEOS THERAPEUTICS INC COM 46565G104   5,444 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100   317 1,747 SH   DFND 1,2,3,4,5,6 1,747 0 0
KE HLDGS INC SPONSORED ADS 482497104   5,181 275,000 SH   DFND 1,2,3,4,5,6 275,000 0 0
KINETA INC COM 49461C102   103 31,055 SH   DFND 1,2,3,4,5,6 31,055 0 0
KINNATE BIOPHARMA INC COM 49705R105   781 125,000 SH   DFND 1,2,3,4,5,6 125,000 0 0
KRONOS BIO INC COM 50107A104   2,253 1,542,954 SH   DFND 1,2,3,4,5,6 1,542,954 0 0
KRYSTAL BIOTECH INC COM 501147102   32,991 412,082 SH   DFND 1,2,3,4,5,6 412,082 0 0
KURA ONCOLOGY INC COM 50127T109   21,012 1,718,056 SH   DFND 1,2,3,4,5,6 1,718,056 0 0
KYMERA THERAPEUTICS INC COM 501575104   53,492 1,805,346 SH   DFND 1,2,3,4,5,6 1,805,346 0 0
LAVA THERAPEUTICS NV SHS N51517105   332 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
LEAP THERAPEUTICS INC COM 52187K101   1,360 4,000,000 SH   DFND 1,2,3,4,5,6 4,000,000 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   8,544 3,516,214 SH   DFND 1,2,3,4,5,6 3,516,214 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   209,617 86,262,020 SH   DFND 1,2,3,4 67,662,150 0 0
MERSANA THERAPEUTICS INC COM 59045L106   9,107 2,215,788 SH   DFND 1,2,3,4,5,6 2,215,788 0 0
METACRINE INC COM 59101E103   528 924,898 SH   DFND 1,2,3,4,5,6 924,898 0 0
MINK THERAPEUTICS INC COM 603693102   549 289,588 SH   DFND 1,2,3,4,5,6 289,588 0 0
MIRATI THERAPEUTICS INC COM 60468T105   57,172 1,537,709 SH   DFND 1,2,3,4,5,6 1,537,709 0 0
MORPHIC HLDG INC COM 61775R105   68,277 1,813,949 SH   DFND 1,2,3,4,5,6 1,813,949 0 0
NANOBIOTIX SPONSORED ADS 63009J107   3,525 1,000,000 SH   DFND 1,2,3,4,5,6 1,000,000 0 0
NATERA INC COM 632307104   11,104 200,000 SH   DFND 1,2,3,4,5,6 200,000 0 0
OMEGA THERAPEUTICS INC COM 68217N105   15,274 2,533,045 SH   DFND 1,2,3,4,5,6 2,533,045 0 0
OVID THERAPEUTICS INC COM 690469101   6,450 2,500,000 SH   DFND 1,2,3,4,5,6 2,500,000 0 0
PLIANT THERAPEUTICS INC COM 729139105   6,785 255,085 SH   DFND 1,2,3,4,5,6 255,085 0 0
PORTAGE FINTECH ACQUISITN CO CLASS A ORD SHS G7185D106   3,891 380,000 SH   DFND 1,2,3,4,5,6 380,000 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108   13,067 121,756 SH   DFND 1,2,3,4,5,6 121,756 0 0
PROTHENA CORP PLC SHS G72800108   133 2,746 SH   DFND 1,2,3,4,5,6 2,746 0 0
RELAY THERAPEUTICS INC COM 75943R102   27,567 1,673,743 SH   DFND 1,2,3,4,5,6 1,673,743 0 0
REPARE THERAPEUTICS INC COM 760273102   6,888 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
REPLIMUNE GROUP INC COM 76029N106   8,830 500,000 SH   DFND 1,2,3,4,5,6 500,000 0 0
REVOLUTION MEDICINES INC COM 76155X100   44,858 2,070,988 SH   DFND 1,2,3,4,5,6 2,070,988 0 0
ROIVANT SCIENCES LTD SHS G76279101   4,428 600,000 SH   DFND 1,2,3,4,5,6 600,000 0 0
RUBIUS THERAPEUTICS INC COM 78116T103   44 2,042,666 SH   DFND 1,2,3,4,5,6 2,042,666 0 0
SAGE THERAPEUTICS INC COM 78667J108   31,470 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
SANA BIOTECHNOLOGY INC COM 799566104   1,308 400,000 SH   DFND 1,2,3,4,5,6 400,000 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   72,224 9,027,950 SH   DFND 1,2,3,4,5,6 9,027,950 0 0
SCHRODINGER INC COM 80810D103   18,431 700,000 SH   DFND 1,2,3,4,5,6 700,000 0 0
SEA LTD SPONSORED ADS 81141R100   26,181 302,500 SH   DFND 1,2,3,4,5,6 302,500 0 0
SEER INC COM CL A 81578P106   18,335 4,750,000 SH   DFND 1,2,3,4,5,6 4,750,000 0 0
SELECTA BIOSCIENCES INC COM 816212104   6,788 4,883,200 SH   DFND 1,2,3,4,5,6 4,883,200 0 0
SENTI BIOSCIENCES INC COM 81726A100   66 55,555 SH   DFND 1,2,3,4,5,6 55,555 0 0
SILENCE THERAPEUTICS PLC ADS 82686Q101   3,131 505,074 SH   DFND 1,2,3,4,5,6 505,074 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   4,310 909,219 SH   DFND 1,2,3,4,5,6 909,219 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   46,779 1,817,349 SH   DFND 1,2,3,4,5,6 1,817,349 0 0
SQZ BIOTECHNOLOGIES CO COM 78472W104   900 1,606,309 SH   DFND 1,2,3,4,5,6 1,606,309 0 0
STOKE THERAPEUTICS INC COM 86150R107   2,083 250,000 SH   DFND 1,2,3,4,5,6 250,000 0 0
STRUCTURE THERAPEUTICS INC SPONSORED ADS 86366E106   1,784 75,000 SH   DFND 1,2,3,4,5,6 75,000 0 0
SYROS PHARMACEUTICALS INC COM NEW 87184Q206   3,940 1,475,744 SH   DFND 1,2,3,4,5,6 1,475,744 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   2,791 30,000 SH   DFND 1,2,3,4,5,6 30,000 0 0
TALARIS THERAPEUTICS INC COM 87410C104   1,719 914,262 SH   DFND 1,2,3,4,5,6 914,262 0 0
TAYSHA GENE THERAPIES INC COM SHS 877619106   1,149 1,440,882 SH   DFND 1,2,3,4,5,6 1,440,882 0 0
TCR2 THERAPEUTICS INC COM 87808K106   1,125 750,000 SH   DFND 1,2,3,4,5,6 750,000 0 0
TG THERAPEUTICS INC COM 88322Q108   7,691 511,389 SH   DFND 1,2,3,4,5,6 511,389 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   11,510 511,784 SH   DFND 1,2,3,4,5,6 511,784 0 0
UNITED THERAPEUTICS CORP COM 91307C102   735 3,281 SH   DFND 1,2,3,4,5,6 3,281 0 0
VENTYX BIOSCIENCES INC COM 92332V107   17,950 535,812 SH   DFND 1,2,3,4,5,6 535,812 0 0
VERVE THERAPEUTICS INC COM 92539P101   4,326 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
VIGIL NEUROSCIENCE INC COM 92673K108   21,962 2,243,352 SH   DFND 1,2,3,4,5,6 2,243,352 0 0
VIKING THERAPEUTICS INC COM 92686J106   4,995 300,000 SH   DFND 1,2,3,4,5,6 300,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   12,847 504,978 SH   DFND 1,2,3,4,5,6 504,978 0 0
VOR BIOPHARMA INC COM 929033108   15,025 2,792,805 SH   DFND 1,2,3,4,5,6 2,792,805 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   12,990 3,000,000 SH   DFND 1,2,3,4,5,6 3,000,000 0 0
WW INTL INC COM 98262P101   61,051 14,818,300 SH   DFND 1,2,3,4,6 14,818,300 0 0
XILIO THERAPEUTICS INC COM 98422T100   1,427 450,000 SH   DFND 1,2,3,4,5,6 450,000 0 0