The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AKERO THERAPEUTICS INC COM 00973Y108   2,287,068 59,777 SH   SOLE   59,777 0 0
ALLOGENE THERAPEUTICS INC COM 019770106   1,210,300 245,000 SH   SOLE   245,000 0 0
ABBOTT LABS COM 002824100   849,976 8,394 SH   SOLE   8,394 0 0
AMEDISYS INC COM 023436108   705,344 9,590 SH   SOLE   9,590 0 0
ALPHABET INC CAP STK CL C 02079K107   318,136 3,059 SH   SOLE   3,059 0 0
APPLIED THERAPEUTICS INC COM 03828A101   1,932,544 2,382,621 SH   SOLE   2,382,621 0 0
APPLE INC COM 037833100   231,520 1,404 SH   SOLE   1,404 0 0
ABBVIE INC COM 00287Y109   1,537,283 9,646 SH   SOLE   9,646 0 0
AMAZON COM INC COM 023135106   299,128 2,896 SH   SOLE   2,896 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   163,500 150,000 SH   SOLE   150,000 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   214,743 1,072 SH   SOLE   1,072 0 0
ADVANCED MICRO DEVICES INC COM 007903107   356,658 3,639 SH   SOLE   3,639 0 0
ADICET BIO INC COM 007002108   154,944 26,900 SH   SOLE   26,900 0 0
ANNEXON INC COM 03589W102   2,515,910 653,483 SH   SOLE   653,483 0 0
AMGEN INC COM 031162100   250,211 1,035 SH   SOLE   1,035 0 0
AGILENT TECHNOLOGIES INC COM 00846U101   379,402 2,747 SH   SOLE   2,747 0 0
INVESCO QQQ TR UNIT SER 1 46090E103   8,838,412 27,540 SH   SOLE   27,540 0 0
RESMED INC COM 761152107   782,232 3,572 SH   SOLE   3,572 0 0
MERCK & CO INC COM 58933Y105   303,318 2,851 SH   SOLE   2,851 0 0
QUIDELORTHO CORP COM 219798105   262,816 2,950 SH   SOLE   2,950 0 0
KURA ONCOLOGY INC COM 50127T109   978,400 80,000 SH   SOLE   80,000 0 0
MEDTRONIC PLC SHS G5960L103   1,993,168 24,723 SH   SOLE   24,723 0 0
BECTON DICKINSON & CO COM 075887109   1,501,330 6,065 SH   SOLE   6,065 0 0
ISHARES TR IBONDS DEC23 ETF 46434VAX8   20,152,000 800,000 SH   SOLE   800,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   2,099,259 50,030 SH   SOLE   50,030 0 0
ISHARES TR MBS ETF 464288588   618,682 6,531 SH   SOLE   6,531 0 0
DATADOG INC CL A COM 23804L103   63,578 875 SH   SOLE   875 0 0
MICROSOFT CORP COM 594918104   772,644 2,680 SH   SOLE   2,680 0 0
MARINUS PHARMACEUTICALS INC COM NEW 56854Q200   1,035,000 150,000 SH   SOLE   150,000 0 0
IQVIA HLDGS INC COM 46266C105   1,596,092 8,025 SH   SOLE   8,025 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   656,265 9,688 SH   SOLE   9,688 0 0
ATAI LIFE SCIENCES NV SHS N0731H103   253,400 140,000 SH   SOLE   140,000 0 0
PERKINELMER INC COM 714046109   904,569 6,788 SH   SOLE   6,788 0 0
ISHARES TR MSCI EAFE ETF 464287465   10,248,816 143,300 SH Put SOLE   143,300 0 0
NVIDIA CORPORATION COM 67066G104   428,321 1,542 SH   SOLE   1,542 0 0
COOPER COS INC COM NEW 216648402   1,135,388 3,041 SH   SOLE   3,041 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105   408,074 2,973 SH   SOLE   2,973 0 0
ISHARES TR CORE MSCI EAFE 46432F842   21,158,426 316,506 SH   SOLE   316,506 0 0
REPLIMUNE GROUP INC COM 76029N106   2,649,000 150,000 SH   SOLE   150,000 0 0
ISHARES TR CORE S&P500 ETF 464287200   327,184,738 795,915 SH   SOLE   795,915 0 0
GILEAD SCIENCES INC COM 375558103   700,101 8,438 SH   SOLE   8,438 0 0
ISHARES TR IBOXX HI YD ETF 464288513   27,198,000 360,000 SH Put SOLE   360,000 0 0
ISHARES TR 20 YR TR BD ETF 464287432   25,369,245 238,500 SH Put SOLE   238,500 0 0
IDEXX LABS INC COM 45168D104   1,469,735 2,939 SH   SOLE   2,939 0 0
FULCRUM THERAPEUTICS INC COM 359616109   1,821,486 639,118 SH   SOLE   639,118 0 0
ISHARES TR MSCI EMG MKT ETF 464287234   2,229,490 56,500 SH Put SOLE   56,500 0 0
KAYNE ANDERSON ENERGY INFRST COM 486606106   1,833,736 212,238 SH   SOLE   212,238 0 0
AVIDITY BIOSCIENCES INC COM 05370A108   1,918,750 125,000 SH   SOLE   125,000 0 0
ISHARES GOLD TR ISHARES NEW 464285204   2,301,245 61,580 SH   SOLE   61,580 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   1,681,400 70,000 SH   SOLE   70,000 0 0
HUMANA INC COM 444859102   609,252 1,255 SH   SOLE   1,255 0 0
ISHARES TR FLTG RATE NT ETF 46429B655   226,755 4,500 SH   SOLE   4,500 0 0
ISHARES TR IBOXX INV CP ETF 464287242   6,905,430 63,000 SH Call SOLE   63,000 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105   672,574 4,900 SH Call SOLE   4,900 0 0
INSULET CORP COM 45784P101   214,660 673 SH   SOLE   673 0 0
CYBIN INC COM 23256X100   192,500 500,000 SH   SOLE   500,000 0 0
ISHARES TR IBONDS DEC24 ETF 46434VBG4   19,672,000 800,000 SH   SOLE   800,000 0 0
DEXCOM INC COM 252131107   1,102,316 9,488 SH   SOLE   9,488 0 0
ATHIRA PHARMA INC COM 04746L104   3,475,370 1,390,148 SH   SOLE   1,390,148 0 0
ISHARES TR CORE US AGGBD ET 464287226   619,860 6,221 SH   SOLE   6,221 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   1,698,856 237,935 SH   SOLE   237,935 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   3,462,864 14,294 SH   SOLE   14,294 0 0
HERON THERAPEUTICS INC COM 427746102   462,951 306,590 SH   SOLE   306,590 0 0
ISHARES TR CORE S&P SCP ETF 464287804   3,332,572 34,463 SH   SOLE   34,463 0 0
BOSTON SCIENTIFIC CORP COM 101137107   444,567 8,886 SH   SOLE   8,886 0 0
ISHARES INC CORE MSCI EMKT 46434G103   5,845,384 119,807 SH   SOLE   119,807 0 0
CLOUDFLARE INC CL A COM 18915M107   433,840 7,036 SH   SOLE   7,036 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101   5,532,072 66,300 SH Put SOLE   66,300 0 0
CHARLES RIV LABS INTL INC COM 159864107   398,998 1,977 SH   SOLE   1,977 0 0
AUTONATION INC COM 05329W102   2,015,400 15,000 SH Put SOLE   15,000 0 0
OMEGA THERAPEUTICS INC COMMON STOCK 68217N105   167,990 27,859 SH   SOLE   27,859 0 0
PALANTIR TECHNOLOGIES INC CL A 69608A108   149,666 17,712 SH   SOLE   17,712 0 0
ELEVANCE HEALTH INC COM 036752103   744,432 1,619 SH   SOLE   1,619 0 0
CLOUDFLARE INC CL A COM 18915M107   1,220,868 19,800 SH Call SOLE   19,800 0 0
LEMONADE INC COM 52567D107   165,345 11,595 SH   SOLE   11,595 0 0
LILLY ELI & CO COM 532457108   1,867,175 5,437 SH   SOLE   5,437 0 0
PURECYCLE TECHNOLOGIES INC COM 74623V103   487,844 69,692 SH   SOLE   69,692 0 0
JOHNSON & JOHNSON COM 478160104   1,879,220 12,124 SH   SOLE   12,124 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105   986,279 1,099,653 SH   SOLE   1,099,653 0 0
REGENERON PHARMACEUTICALS COM 75886F107   3,123,989 3,802 SH   SOLE   3,802 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   578,750 25,000 SH   SOLE   25,000 0 0
ATRICURE INC COM 04963C209   363,434 8,768 SH   SOLE   8,768 0 0
ISHARES TR IBOXX INV CP ETF 464287242   622,037 5,675 SH   SOLE   5,675 0 0
PLAINS GP HLDGS L P LTD PARTNR INT A 72651A207   13,833,689 1,054,397 SH   SOLE   1,054,397 0 0
BIO-TECHNE CORP COM 09073M104   258,478 3,484 SH   SOLE   3,484 0 0
DATADOG INC CL A COM 23804L103   457,758 6,300 SH Call SOLE   6,300 0 0
KYMERA THERAPEUTICS INC COM 501575104   312,063 10,532 SH   SOLE   10,532 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   2,418,024 9,465 SH   SOLE   9,465 0 0
UNITEDHEALTH GROUP INC COM 91324P102   1,258,035 2,662 SH   SOLE   2,662 0 0
SIMPLIFY EXCHANGE TRADED FUN MANAGED FUTURES 82889N699   4,961,995 211,870 SH   SOLE   211,870 0 0
STARWOOD PPTY TR INC COM 85571B105   2,388,150 135,000 SH Put SOLE   135,000 0 0
SUTRO BIOPHARMA INC COM 869367102   554,400 120,000 SH   SOLE   120,000 0 0
SNOWFLAKE INC CL A 833445109   383,102 2,483 SH   SOLE   2,483 0 0
X4 PHARMACEUTICALS INC COM 98420X103   348,000 400,000 SH   SOLE   400,000 0 0
SERES THERAPEUTICS INC COM 81750R102   3,122,049 550,626 SH   SOLE   550,626 0 0
SIMPLIFY EXCHANGE TRADED FUN AGGREGATE BOND P 82889N723   4,617,825 202,411 SH   SOLE   202,411 0 0
SANOFI SPONSORED ADR 80105N105   3,310,750 60,837 SH   SOLE   60,837 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   995,391 1,727 SH   SOLE   1,727 0 0
TESLA INC COM 88160R101   33,338,822 160,700 SH Call SOLE   160,700 0 0
SIMPLIFY EXCHANGE TRADED FUN HIGH YIELD PLUS 82889N830   8,892,896 405,498 SH   SOLE   405,498 0 0
SONDER HOLDINGS INC CLASS A COM 83542D102   175,035 231,191 SH   SOLE   231,191 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   21,370,158 52,200 SH Call SOLE   52,200 0 0
SIMPLIFY EXCHANGE TRADED FUN SIMPLIFY INTERST 82889N855   4,855,033 79,656 SH   SOLE   79,656 0 0
SIMPLIFY EXCHANGE TRADED FUN STABLE INCM ETF 82889N640   1,794,879 71,759 SH   SOLE   71,759 0 0
SPDR SER TR BLOOMBERG INVT 78468R200   1,870,836 61,480 SH   SOLE   61,480 0 0
VANGUARD BD INDEX FDS SHORT TRM BOND 921937827   618,575 8,087 SH   SOLE   8,087 0 0
STOKE THERAPEUTICS INC COM 86150R107   1,022,891 122,796 SH   SOLE   122,796 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   475,301 7,999 SH   SOLE   7,999 0 0
SIMPLIFY EXCHANGE TRADED FUN VOLATILITY PREM 82889N863   10,745,827 494,061 SH   SOLE   494,061 0 0
TSCAN THERAPEUTICS INC COM 89854M101   1,148,524 546,916 SH   SOLE   546,916 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   1,511,252 11,697 SH   SOLE   11,697 0 0
TALON 1 ACQUISITION CORP CLASS A ORD G86656108   12,863 47,640 SH   SOLE   47,640 0 0
SIMPLIFY EXCHANGE TRADED FUN COMMODITIES STRA 82889N566   2,491,500 100,000 SH   SOLE   100,000 0 0
TESLA INC COM 88160R101   345,421 1,665 SH   SOLE   1,665 0 0
WATERS CORP COM 941848103   373,414 1,206 SH   SOLE   1,206 0 0
SIMPLIFY EXCHANGE TRADED FUN INTMD TERM TRSRY 82889N798   2,533,369 155,708 SH   SOLE   155,708 0 0
STRYKER CORPORATION COM 863667101   577,220 2,022 SH   SOLE   2,022 0 0
SIMPLIFY EXCHANGE TRADED FUN ENHANCED INM ETF 82889N632   1,778,692 71,332 SH   SOLE   71,332 0 0
SIMPLIFY EXCHANGE TRADED FUN SHORT TERM TREA 82889N657   6,220,255 245,168 SH   SOLE   245,168 0 0